ATP5PO

Protein identityUniProt · HPA

UniProt accession

P48047

Gene

ATP5PO

Ensembl

ENSG00000241837

Chromosome

21

Canonical length

213 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters

Subcellular location

Mitochondria

Quaternary structure

Homooctamer

OverviewNCBI Gene

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>P48047|ATP5PO
     1  MAAPAVSGLS RQVRCFSTSV VRPFAKLVRP PVQVYGIEGR YATALYSAAS KQNKLEQVEK
    61  ELLRVAQILK EPKVAASVLN PYVKRSIKVK SLNDITAKER FSPLTTNLIN LLAENGRLSN
   121  TQGVVSAFST MMSVHRGEVP CTVTSASPLE EATLSELKTV LKSFLSQGQV LKLEAKTDPS
   181  ILGGMIVRIG EKYVDMSVKT KIQKLGRAMR EIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5PO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

1,494 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATP5PO.

Disease | AllUniProt

Conditions ATP5PO is implicated in, by any mechanism.

• Mitochondrial complex V deficiency, nuclear type 7 (MC5DN7) MIM:620359

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 54 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Mitochondrial complex V (ATP synthase) deficiency, nuclear type 7
• Dysphagia
• Severe global developmental delay
• Seizure
• Microcephaly

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.78

gnomAD pLI

0.06

DepMap mean gene effect

-0.37

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ATP biosynthetic process
• cellular response to cAMP
• cellular response to cytokine stimulus
• proton motive force-driven ATP synthesis
• proton motive force-driven mitochondrial ATP synthesis
• proton transmembrane transport

Molecular functions

• ATP hydrolysis activity
• estradiol binding
• protein-containing complex binding
• proton-transporting ATP synthase activity, rotational mechanism

Cellular components

• cell surface
• mitochondrial inner membrane
• mitochondrion
• nucleus
• plasma membrane
• proton-transporting ATP synthase complex

Protein domainsUniProt · Pfam · InterPro

• ATPase, OSCP/delta subunit
• ATPase, OSCP/delta subunit, conserved site
• F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily
• ATP synthase delta (OSCP) subunit

KeywordsUniProt

• Acetylation
• ATP synthesis
• Hydrogen ion transport
• Ion transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Primary mitochondrial disease
• Transit peptide
• Transport
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of ATP5PO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP5F1A
• ATP5PB
• ATP5PF
• RER1
• RTN4
• STOM