Seroatlas · Human Serome Atlas

ATG101

Autophagy-related protein 101

Also known as: ATGA1_HUMAN, C12orf44, FLJ11773

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSB4
Gene: ATG101
Ensembl: ENSG00000123395
Chromosome: 12
Canonical length: 218 aa
Protein class: Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Enables identical protein binding activity. Involved in autophagosome assembly and negative regulation of cell population proliferation. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. Biomarker of cholangiocarcinoma; colon cancer; and hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q9BSB4|ATG101
     1  MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV GTQDVDCDFI
    61  DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL EFYQKKKSRW PFSDECIPWE
   121  VWTVKVHVVA LATEQERQIC REKVGEKLCE KIINIVEVMN RHEYLPKMPT QSEVDNVFDT
   181  GLRDVQPYLY KISFQITDAL GTSVTTTMRR LIKDTLAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG101 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

skin: 42 nTPM
choroid plexus: 39 nTPM
stomach: 38 nTPM
skeletal muscle: 38 nTPM
liver: 36 nTPM
salivary gland: 36 nTPM

Single-cell type

epididymal principal cells: 198 nCPM
esophageal apical cells: 143 nCPM
basal keratinocytes: 137 nCPM
suprabasal keratinocytes: 136 nCPM
pdcs: 124 nCPM
esophageal suprabasal cells: 111 nCPM

Immune cell

plasmacytoid DC: 262 nTPM
myeloid DC: 49 nTPM
non-classical monocyte: 47 nTPM
naive B-cell: 46 nTPM
eosinophil: 46 nTPM
memory B-cell: 40 nTPM

Brain region

cerebral cortex: 26 nTPM
white matter: 21 nTPM
hippocampal formation: 21 nTPM
basal ganglia: 20 nTPM
thalamus: 19 nTPM
cerebellum: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.61
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Autophagy-related protein 101
Autophagy-related protein 101

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG101 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG101 as an antibody target. Whether an autoantibody or antibody against ATG101 could matter depends on whether native ATG101 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG101 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG101 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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