Seroatlas · Human Serome Atlas

UBN2

Ubinuclein-2

Also known as: FLJ25778, KIAA2030, UBN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZU65
Gene: UBN2
Ensembl: ENSG00000157741
Chromosome: 7
Canonical length: 1347 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in chromatin organization. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1347 residues, UniProt reviewed canonical sequence.

>Q6ZU65|UBN2
     1  MAEPRRVAFI SLSPVRRREA EYPGPEREPE YPREPPRLEP QPYREPARAE PPAPREPAPR
    61  SDAQPPSREK PLPQREVSRA EPPMSLQREP PRPEPPPPFP PLPLQPPPPR ESASRAEQPP
   121  RPPRETVRLE LVLKDPTDES CVEFSYPELL LCGEQRKKLI HTEDPFNDEH QERQEVEMLA
   181  KKFEMKYGGK PRKHRKDRLQ DLIDIGFGYD ETDPFIDNSE AYDELVPASL TTKYGGFYIN
   241  TGTLQFRQAS DTEEDDITDN QKHKPPKVPK IKEDDIEMKK RKRKEEGEKE KKPRKKVPKQ
   301  LGVVALNSHK SEKKKKRYKD SLSLAAMIRK FQKEKDALKK ESNPKVPVTL STPSLNKPPC
   361  AAAALGNDVP DLNLSSGDPD LPIFVSTNEH ELFQEAENAL EMLDDFDFDR LLDAASDGSP
   421  LSESGGENGT TTQPTYTSQV MPKVVPTLPE GLPVLLEKRI EDLRVAAKLF DEEGRKKFFT
   481  QDMNNILLDI ELQLQELGPV IRSGVYSHLE AFVPCNKETL VKRLKKLHLN VQDDRLREPL
   541  QKLKLAVSNV MPEQLFKYQE DCQARSQAKC AKLQTDEERE KNGSEEDDDE KPGKRVIGPR
   601  KKFHWDDTIR TLLCNLVEIK LGCYELEPNK SQSAEDYLKS FMETEVKPLW PKGWMQARML
   661  FKESRSVHNH LTSAPAKKKV IPAPKPKVKE VMVKTLPLHS FPTMLKECSP KKDQKTPTSL
   721  VASVSGPPTS SSTAAIAAAS SSSAPAQETI CLDDSLDEDL SFHSPSLDLV SEALAVINNG
   781  NKGPPVGSRI SMPTTKPRPG LREEKLASIM SKLPLATPKK LDSTQTTHSS SLIAGHTGPV
   841  PKKPQDLAHT GISSGLIAGS SIQNPKVSLE PLPARLLQQG LQRSSQIHTS SSSQTHVSSS
   901  SQAQIAASSH ALGTSEAQDA SSLTQVTKVH QHSAVQQNYV SPLQATISKS QTNPVVKLSN
   961  NPQLSCSSSL IKTSDKPLMY RLPLSTPSPG NGSQGSHPLV SRTVPSTTTS SNYLAKAMVS
  1021  QISTQGFKSP FSMAASPKLA ASPKPATSPK PLPSPKPSAS PKPSLSAKPS VSTKLISKSN
  1081  PTPKPTVSPS SSSPNALVAQ GSHSSTNSPV HKQPSGMNIS RQSPTLNLLP SSRTSGLPPT
  1141  KNLQAPSKLT NSSSTGTVGK NSLSGIAMNV PASRGSNLNS SGANRTSLSG GTGSGTQGAT
  1201  KPLSTPHRPS TASGSSVVTA SVQSTAGASL LANASPLTLM TSPLSVTNQN VTPFGMLGGL
  1261  VPVTMPFQFP LEIFGFGTDT AGVTTTSGST SAAFHHSLTQ NLLKGLQPGG AQHAATLSHS
  1321  PLPAHLQQAF HDGGQSKGDT KLPRKSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
retina: 13 nTPM
skin: 9.1 nTPM
cerebellum: 8.4 nTPM
pituitary gland: 7.8 nTPM
skeletal muscle: 6.8 nTPM

Single-cell type

late spermatids: 277 nCPM
lactotrophs: 239 nCPM
thyrotrophs: 232 nCPM
somatotrophs: 230 nCPM
myonuclei: 204 nCPM
corticotrophs: 170 nCPM

Immune cell

basophil: 8.4 nTPM
NK-cell: 1.9 nTPM
plasmacytoid DC: 0.7 nTPM
classical monocyte: 0.6 nTPM
naive B-cell: 0.6 nTPM
memory B-cell: 0.5 nTPM

Brain region

cerebellum: 50 nTPM
white matter: 40 nTPM
cerebral cortex: 36 nTPM
hypothalamus: 35 nTPM
amygdala: 33 nTPM
basal ganglia: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBN2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 247 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autism spectrum disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 0.19
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBN2 as an antibody target. Whether an autoantibody or antibody against UBN2 could matter depends on whether native UBN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBN2 is annotated as secreted, so native UBN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label UBN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...