Arfaptin homology (AH) domain

Definition

The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 PMID:10623590 and mammalian 69kDa islet cell autoantigen (ICA69) PMID:12682071. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [[cite:PMID:11346801], [cite:PMID:11696355]], including ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The AH domain consists of three α-helices arranged as an extended antiparallel α-helical bundle. Two arfaptin AH domains associate to form a highly elongated, crescent-shaped dimer [[cite:PMID:11346801], [cite:PMID:11696355]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• ARFIP1
• ARFIP2
• ICA1
• ICA1L
• PICK1