Haemolysin-III related
PF03006
Definition
Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus PMID:7495855. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism PMID:11916977. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins PMID:16044242. The mammalian members include progesterone binding proteins PMID:17082257. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily PMID:21733186, which are distantly related to GPCRs.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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