Seroatlas · Human Serome Atlas

PAQR4

Progestin and adipoQ receptor family member 4

Also known as: FLJ30002, PAQR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4S7
Gene: PAQR4
Ensembl: ENSG00000162073
Chromosome: 16
Canonical length: 273 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables molecular adaptor activity. Involved in protein stabilization and regulation of ceramide biosynthetic process. Located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q8N4S7|PAQR4
     1  MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG NIYTHGLALL
    61  GFLVLVPMTM PWGQLGKDGW LGGTHCVACL APPAGSVLYH LFMCHQGGSA VYARLLALDM
   121  CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL VGYTVLSGVA GWRALTAPST SARLRAFGWQ
   181  AAARLLVFGA RGVGLGSGAP GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH
   241  QIMHLLSVGS ILQLHAGVVP DLLWAAHHAC PRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAQR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 144 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 144 nTPM
midbrain: 61 nTPM
retina: 59 nTPM
hippocampal formation: 57 nTPM
cerebral cortex: 39 nTPM
basal ganglia: 39 nTPM

Single-cell type

respiratory deuterosomal cells: 106 nCPM
tuft cells: 92 nCPM
retinal pigment epithelial cells: 85 nCPM
rod photoreceptor cells: 74 nCPM
oligodendrocytes: 61 nCPM
cone photoreceptor cells: 50 nCPM

Immune cell

non-classical monocyte: 3.6 nTPM
classical monocyte: 0.4 nTPM
myeloid DC: 0.4 nTPM
total PBMC: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
memory B-cell: 0.2 nTPM

Brain region

white matter: 200 nTPM
medulla oblongata: 143 nTPM
cerebellum: 115 nTPM
basal ganglia: 114 nTPM
midbrain: 109 nTPM
pons: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molecular adaptor activity

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAQR4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAQR4 as an antibody target. Whether an autoantibody or antibody against PAQR4 could matter depends on whether native PAQR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAQR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAQR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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