ADIPOR1

Protein identityUniProt · HPA

UniProt accession

Q96A54

Gene

ADIPOR1

Ensembl

ENSG00000159346

Chromosome

1

Canonical length

375 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Quaternary structure

Homooligomer

OverviewNCBI Gene

This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q96A54|ADIPOR1
     1  MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE EQTCPVPQEE
    61  EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL PDWLKDNDYL LHGHRPPMPS
   121  FRACFKSIFR IHTETGNIWT HLLGFVLFLF LGILTMLRPN MYFMAPLQEK VVFGMFFLGA
   181  VLCLSFSWLF HTVYCHSEKV SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS
   241  IVCVLGISAI IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM
   301  GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV HFYGVSNLQE
   361  FRYGLEGGCT DDTLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADIPOR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

203 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0.66

gnomAD missense Z

2.82

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adiponectin-activated signaling pathway
• fatty acid oxidation
• glucose homeostasis
• hormone-mediated signaling pathway
• leptin-mediated signaling pathway
• negative regulation of cell growth
• negative regulation of epithelial cell migration
• negative regulation of epithelial to mesenchymal transition
• negative regulation of non-canonical NF-kappaB signal transduction
• negative regulation of receptor signaling pathway via JAK-STAT
• positive regulation of cold-induced thermogenesis
• positive regulation of insulin receptor signaling pathway
• positive regulation of receptor signaling pathway via JAK-STAT
• regulation of glucose metabolic process
• regulation of lipid metabolic process

Molecular functions

• adipokinetic hormone receptor activity
• adiponectin binding
• identical protein binding
• metal ion binding
• protein kinase binding
• signaling receptor activity

Cellular components

• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• AdipoR/Haemolysin-III-related
• Haemolysin-III related

KeywordsUniProt

• Cell membrane
• Fatty acid metabolism
• Lipid metabolism
• Membrane
• Metal-binding
• Receptor
• Transmembrane
• Transmembrane helix
• Zinc

InteractionsUniProt · HPA

Protein binding partners of ADIPOR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APPL1
• APPL2