Seroatlas · Human Serome Atlas

PAQR7

Membrane progestin receptor alpha

Also known as: MPRA, mSR, PAQR7_HUMAN, PGLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WK9
Gene: PAQR7
Ensembl: ENSG00000182749
Chromosome: 1
Canonical length: 346 aa
Protein class: Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable nuclear steroid receptor activity and steroid binding activity. Predicted to be involved in response to steroid hormone. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q86WK9|PAQR7
     1  MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF
    61  YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG DPHALPLFII VLASFTYLSF
   121  SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ FGSALAHFYY AIEPAWHAQV QAVFLPMAAF
   181  LAWLSCIGSC YNKYIQKPGL LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY
   241  HKCQVVFFLL AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR
   301  RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAQR7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

testis: 60 nTPM
ovary: 35 nTPM
kidney: 33 nTPM
skin: 30 nTPM
adrenal gland: 28 nTPM
epididymis: 27 nTPM

Single-cell type

late spermatids: 3,372 nCPM
early spermatids: 422 nCPM
tuft cells: 127 nCPM
cytotrophoblasts: 96 nCPM
sertoli cells: 81 nCPM
ependymal cells: 63 nCPM

Immune cell

non-classical monocyte: 17 nTPM
eosinophil: 16 nTPM
intermediate monocyte: 14 nTPM
myeloid DC: 7.5 nTPM
classical monocyte: 7.2 nTPM
basophil: 5.3 nTPM

Brain region

hypothalamus: 17 nTPM
midbrain: 17 nTPM
choroid plexus: 16 nTPM
medulla oblongata: 15 nTPM
pons: 15 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAQR7 as an antibody target. Whether an autoantibody or antibody against PAQR7 could matter depends on whether native PAQR7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAQR7 is annotated at the cell surface, where native PAQR7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PAQR7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...