PAQR8
Membrane progestin receptor beta
Also known as: C6orf33, LMPB1, MPRB, PAQR8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TEZ7
- Gene
- PAQR8
- Ensembl
- ENSG00000170915
- Chromosome
- 6
- Canonical length
- 354 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Golgi apparatus,Plasma membrane
OverviewNCBI Gene
Predicted to enable nuclear steroid receptor activity and steroid binding activity. Predicted to be involved in response to steroid hormone. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
354 residues, UniProt reviewed canonical sequence.
>Q8TEZ7|PAQR8
1 MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY IRTGYRPTGH
61 EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE ALPWASTHSL PLLLFILSSI
121 TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL
181 PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC
241 QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI
301 LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT KKDSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PAQR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 139 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 139 nTPM
- midbrain: 72 nTPM
- basal ganglia: 60 nTPM
- hippocampal formation: 51 nTPM
- amygdala: 48 nTPM
- cerebral cortex: 44 nTPM
Single-cell type
- medullary thymic epithelial cells: 2.4 nCPM
- enterocytes: 2 nCPM
- foveolar cells: 1.6 nCPM
- oligodendrocytes: 1.1 nCPM
- bergmann glia: 0.9 nCPM
- colonocytes: 0.8 nCPM
Immune cell
- naive CD4 T-cell: 18 nTPM
- NK-cell: 8.5 nTPM
- memory CD4 T-cell: 8.3 nTPM
- naive CD8 T-cell: 8.3 nTPM
- myeloid DC: 7 nTPM
- T-reg: 6.2 nTPM
Brain region
- white matter: 228 nTPM
- medulla oblongata: 213 nTPM
- cerebellum: 189 nTPM
- pons: 170 nTPM
- basal ganglia: 168 nTPM
- midbrain: 162 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.76
- gnomAD pLI
- 0.15
- gnomAD missense Z
- 0.85
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PAQR8 as an antibody target. Whether an autoantibody or antibody against PAQR8 could matter depends on whether native PAQR8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PAQR8 is annotated at the cell surface, where native PAQR8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PAQR8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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