Seroatlas · Human Serome Atlas

PAQR3

Progestin and adipoQ receptor family member 3

Also known as: PAQR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6TCH7
Gene: PAQR3
Ensembl: ENSG00000163291
Chromosome: 4
Canonical length: 311 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q6TCH7|PAQR3
     1  MHQKLLKSAH YIELGSYQYW PVLVPRGIRL YTYEQIPGSL KDNPYITDGY RAYLPSRLCI
    61  KSLFILSNET VNIWSHLLGF FLFFTLGIYD MTSVLPSASA SREDFVICSI CLFCFQVCML
   121  CSVGYHLFSC HRSEKTCRRW MALDYAGISI GILGCYVSGV FYAFYCNNYW RQVYLITVLA
   181  MILAVFFAQI HPNYLTQQWQ RLRSIIFCSV SGYGVIPTLH WVWLNGGIGA PIVQDFAPRV
   241  IVMYMIALLA FLFYISKVPE RYFPGQLNYL GSSHQIWHIL AVVMLYWWHQ STVYVMQYRH
   301  SKPCPDYVSH L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAQR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 2.9 nTPM
midbrain: 2.9 nTPM
amygdala: 2.8 nTPM
spleen: 2.3 nTPM
spinal cord: 2.2 nTPM
cerebral cortex: 2.1 nTPM

Single-cell type

late spermatids: 231 nCPM
cardiomyocytes: 172 nCPM
mast cells: 139 nCPM
early spermatids: 131 nCPM
epicardial cells: 82 nCPM
hofbauer cells: 65 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2 nTPM
white matter: 1.8 nTPM
spinal cord: 1.7 nTPM
cerebral cortex: 1.4 nTPM
medulla oblongata: 1.2 nTPM
pons: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAQR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAQR3 as an antibody target. Whether an autoantibody or antibody against PAQR3 could matter depends on whether native PAQR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAQR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAQR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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