Seroatlas · Human Serome Atlas

PAQR9

Membrane progestin receptor epsilon

Also known as: BLNC1, FLJ41938, PAQR9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVX9
Gene: PAQR9
Ensembl: ENSG00000188582
Chromosome: 3
Canonical length: 377 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q6ZVX9|PAQR9
     1  MPRRLQPRGA GTKGPPAPAP AASGAARNSH SAASRDPPAS AKPLLRWDEV PDDFVECFIL
    61  SGYRRLPCTA QECLASVLKP TNETLNFWTH FIPLLLFLSK FCRLFFLSGG DVPFHHPWLL
   121  PLWCYASGVL LTFAMSCTAH VFSCLSLRLR AAFFYLDYAS ISYYGFGSTV AYYYYLLPGL
   181  SLLDARVMTP YLQQRLGWHV DCTRLIAAYR ALVLPVAFVL AVACTVACCK SRTDWCTYPF
   241  ALRTFVFVMP LSMACPIMLE SWLFDLRGEN PTLFVHFYRR YFWLVVAAFF NVSKIPERIQ
   301  PGLFDIIGHS HQLFHIFTFL SIYDQVYYVE EGLRQFLQAP PAAPTFSGTV GYMLLLVVCL
   361  GLVIRKFLNS SEFCSKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAQR9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
liver: 9.6 nTPM
retina: 8.9 nTPM
bone marrow: 4.9 nTPM
heart muscle: 4.7 nTPM
skeletal muscle: 2 nTPM

Single-cell type

late spermatids: 150 nCPM
syncytiotrophoblasts: 65 nCPM
early spermatids: 39 nCPM
late primary spermatocytes: 28 nCPM
hepatocytes: 28 nCPM
corticotrophs: 21 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 18 nTPM
thalamus: 12 nTPM
hippocampal formation: 9.5 nTPM
white matter: 9 nTPM
basal ganglia: 8.8 nTPM
hypothalamus: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.14
gnomAD missense Z: 2.83
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAQR9 as an antibody target. Whether an autoantibody or antibody against PAQR9 could matter depends on whether native PAQR9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAQR9 is annotated at the cell surface, where native PAQR9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PAQR9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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