Seroatlas · Human Serome Atlas

PAQR6

Membrane progestin receptor delta

Also known as: FLJ22672, PAQR6_HUMAN, PRdelta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6TCH4
Gene: PAQR6
Ensembl: ENSG00000160781
Chromosome: 1
Canonical length: 344 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q6TCH4|PAQR6
     1  MLSLKLPQLL QVHQVPRVFW EDGIMSGYRR PTSSALDCVL SSFQMTNETV NIWTHFLPTW
    61  YFLWRLLALA GGPGFRAEPY HWPLLVFLLP ACLYPFASCC AHTFSSMSPR MRHICYFLDY
   121  GALSLYSLGC AFPYAAYSMP ASWLHGHLHQ FFVPAAALNS FLCTGLSCYS RFLELESPGL
   181  SKVLRTGAFA YPFLFDNLPL FYRLGLCWGR GHGCGQEALS TSHGYHLFCA LLTGFLFASH
   241  LPERLAPGRF DYIGHSHQLF HICAVLGTHF QLEAVLADMG SRRAWLATQE PALGLAGTVA
   301  TLVLAAAGNL LIIAAFTATL LRAPSTCPLL QGGPLEGGTQ AKQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAQR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 912 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 912 nTPM
midbrain: 609 nTPM
hippocampal formation: 309 nTPM
amygdala: 279 nTPM
hypothalamus: 274 nTPM
basal ganglia: 242 nTPM

Single-cell type

oligodendrocytes: 65 nCPM
astrocytes: 56 nCPM
müller glia: 53 nCPM
bergmann glia: 50 nCPM
schwann cells: 25 nCPM
ependymal cells: 22 nCPM

Immune cell

NK-cell: 5.7 nTPM
MAIT T-cell: 0.8 nTPM
plasmacytoid DC: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM

Brain region

medulla oblongata: 482 nTPM
pons: 445 nTPM
white matter: 398 nTPM
spinal cord: 392 nTPM
midbrain: 296 nTPM
thalamus: 281 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: 0.75
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAQR6 as an antibody target. Whether an autoantibody or antibody against PAQR6 could matter depends on whether native PAQR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAQR6 is annotated at the cell surface, where native PAQR6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PAQR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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