Seroatlas · Human Serome Atlas

ADIPOR2

Adiponectin receptor protein 2

Also known as: ACDCR2, PAQR2, PAQR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86V24
Gene
ADIPOR2
Ensembl
ENSG00000006831
Chromosome
12
Canonical length
386 aa
Protein class
Predicted membrane proteins, Transporters
Quaternary structure
Homooligomer

OverviewNCBI Gene

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q86V24|ADIPOR2
     1  MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV LSSHHKKSSE
    61  EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF
   121  LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE
   181  KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY
   241  CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE
   301  GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL FHIFVVAGAF
   361  VHFHGVSNLQ EFRFMIGGGC SEEDAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADIPOR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
121 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 121 nTPM
  • liver: 78 nTPM
  • midbrain: 76 nTPM
  • adrenal gland: 70 nTPM
  • hippocampal formation: 58 nTPM
  • adipose tissue: 53 nTPM

Single-cell type

  • oligodendrocytes: 457 nCPM
  • renal collecting duct intercalated cells: 267 nCPM
  • bergmann glia: 142 nCPM
  • microglia: 122 nCPM
  • choroid plexus epithelial cells: 101 nCPM
  • renal connecting tubule cells: 89 nCPM

Immune cell

  • eosinophil: 1.8 nTPM
  • gdT-cell: 0.9 nTPM
  • neutrophil: 0.9 nTPM
  • plasmacytoid DC: 0.9 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • basophil: 0.7 nTPM

Brain region

  • white matter: 93 nTPM
  • medulla oblongata: 64 nTPM
  • basal ganglia: 60 nTPM
  • midbrain: 55 nTPM
  • cerebellum: 55 nTPM
  • pons: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.36
gnomAD missense Z
2.65
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADIPOR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADIPOR2 as an antibody target. Whether an autoantibody or antibody against ADIPOR2 could matter depends on whether native ADIPOR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADIPOR2 is annotated at the cell surface, where native ADIPOR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADIPOR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADIPOR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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