Seroatlas · Human Serome Atlas

MMD2

Monocyte to macrophage differentiation factor 2

Also known as: PAQR10, PAQRA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY49
Gene: MMD2
Ensembl: ENSG00000136297
Chromosome: 7
Canonical length: 270 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q8IY49|MMD2
     1  MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI LGSSNLYFLS
    61  DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE HCLHMFDRMV IYFFIAASYA
   121  PWLNLRELGP WASHMRWLVW IMASVGTIYV FFFHERTGSC VQFLRGEACP KAGTACLPAR
   181  YKLVELLCYV VMGFFPALVI LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH
   241  LFVAFGAGTH YYAIWRYLYL PSTLQTKVSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 28 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 19 nTPM
amygdala: 17 nTPM
midbrain: 12 nTPM
hippocampal formation: 12 nTPM

Single-cell type

sertoli cells: 443 nCPM
astrocytes: 308 nCPM
oligodendrocyte progenitor cells: 194 nCPM
cone photoreceptor cells: 170 nCPM
lactotrophs: 156 nCPM
bergmann glia: 139 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 66 nTPM
medulla oblongata: 65 nTPM
basal ganglia: 63 nTPM
midbrain: 59 nTPM
amygdala: 59 nTPM
hippocampal formation: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: 0.08
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

protein kinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMD2 as an antibody target. Whether an autoantibody or antibody against MMD2 could matter depends on whether native MMD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MMD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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