Seroatlas · Human Serome Atlas

PAQR5

Membrane progestin receptor gamma

Also known as: FLJ20190, MPRG, PAQR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXK6
Gene: PAQR5
Ensembl: ENSG00000137819
Chromosome: 15
Canonical length: 330 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q9NXK6|PAQR5
     1  MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL NIWTHLLPFW
    61  FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC AHTFSSMSKN ARHICYFLDY
   121  GAVNLFSLGS AIAYSAYTFP DALMCTTFHD YYVALAVLNT ILSTGLSCYS RFLEIQKPRL
   181  CKVIRVLAFA YPYTWDSLPI FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE
   241  RLAPGRFDYI GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL
   301  LCIIFSLSNI IYFSAALYRI PKPELHKKET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAQR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

kidney: 49 nTPM
colon: 18 nTPM
rectum: 15 nTPM
adrenal gland: 15 nTPM
esophagus: 12 nTPM
parathyroid gland: 11 nTPM

Single-cell type

renal connecting tubule cells: 374 nCPM
distal convoluted tubule cells: 293 nCPM
late spermatids: 226 nCPM
loop of henle epithelial cells: 208 nCPM
renal collecting duct intercalated cells: 196 nCPM
proximal tubule cells: 137 nCPM

Immune cell

basophil: 0.9 nTPM
naive CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 25 nTPM
thalamus: 9.2 nTPM
pons: 8.1 nTPM
amygdala: 6.9 nTPM
medulla oblongata: 6.8 nTPM
midbrain: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.04
gnomAD missense Z: 0.77
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

oogenesis

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAQR5 as an antibody target. Whether an autoantibody or antibody against PAQR5 could matter depends on whether native PAQR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAQR5 is annotated at the cell surface, where native PAQR5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PAQR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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