Seroatlas · Human Serome Atlas

TFG

Protein TFG

Also known as: FLJ36137, SPG57, TF6, TFG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92734
Gene
TFG
Ensembl
ENSG00000114354
Chromosome
3
Canonical length
400 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q92734|TFG
     1  MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS NDEVTIKYKD
    61  EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS QVKYLRRELI ELRNKVNRLL
   121  DSLEPPGEPG PSTNIPENDT VDGREEKSAS DSSGKQSTQV MAASMSAFDP LKNQDEINKN
   181  VMSAFGLTDD QVSGPPSAPA EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE
   241  GQMYQQYQQQ AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP
   301  APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA PSQPGAYQPR
   361  PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
103 nTPM

Expression across tissuesHPA

Tissue

  • liver: 103 nTPM
  • duodenum: 85 nTPM
  • parathyroid gland: 84 nTPM
  • esophagus: 79 nTPM
  • heart muscle: 75 nTPM
  • placenta: 74 nTPM

Single-cell type

  • esophageal apical cells: 402 nCPM
  • syncytiotrophoblasts: 381 nCPM
  • enterocytes: 294 nCPM
  • extravillous trophoblasts: 288 nCPM
  • cytotrophoblasts: 268 nCPM
  • migrating cytotrophoblasts: 256 nCPM

Immune cell

  • basophil: 84 nTPM
  • intermediate monocyte: 45 nTPM
  • non-classical monocyte: 45 nTPM
  • classical monocyte: 44 nTPM
  • NK-cell: 43 nTPM
  • myeloid DC: 43 nTPM

Brain region

  • choroid plexus: 38 nTPM
  • cerebral cortex: 37 nTPM
  • hypothalamus: 36 nTPM
  • medulla oblongata: 33 nTPM
  • pons: 33 nTPM
  • white matter: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TFG.

Disease | AllUniProt

Conditions TFG is implicated in, by any mechanism.

  • Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO) MIM:604484
  • Spastic paraplegia 57, autosomal recessive (SPG57) MIM:615658

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 493 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hereditary motor and sensory neuropathy, Okinawa type
  • Hereditary spastic paraplegia 57
  • Amyotrophic Lateral Sclerosis with Sensory Neuropathy
  • See cases
  • Inborn genetic diseases

Disease | ImmuneIEDB

Conditions an epitope on TFG was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.14
gnomAD missense Z
1.33
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TFG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFG as an antibody target. Whether an autoantibody or antibody against TFG could matter depends on whether native TFG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TFG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TFG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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