Leucine-rich repeat and fibronectin type-III domain-containing
IPR050467
Definition
The LRFN family proteins are involved in various cellular processes, primarily related to neural development and function. They act as cell adhesion molecules, mediating homophilic cell-cell adhesion in a calcium-independent manner, and are crucial for neurite outgrowth in hippocampal neurons. Members of this family are also implicated in the regulation and maintenance of excitatory synapses, often inducing the clustering of postsynaptic proteins. Some LRFN proteins enhance the cell surface expression of NMDA receptor subunits and may influence the redistribution of synaptic proteins to the cell periphery. The presence of a PDZ-binding motif in some family members suggests a role in protein-protein interactions at synapses. Additionally, certain LRFN proteins may have roles in axon guidance, phototransduction, and craniofacial and inner ear morphogenesis. The family includes proteins with leucine-rich repeat and fibronectin type III domains, which are characteristic structural features contributing to their functions.
18 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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