Seroatlas · Human Serome Atlas

GP5

Platelet glycoprotein V

Also known as: CD42d, GPV_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P40197
Gene: GP5
Ensembl: ENSG00000178732
Chromosome: 3
Canonical length: 560 aa
Protein class: CD markers, Plasma proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>P40197|GP5
     1  MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT NLTHILLFGM
    61  GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL KTLRLSRNKI THLPGALLDK
   121  MVLLEQLFLD HNALRGIDQN MFQKLVNLQE LALNQNQLDF LPASLFTNLE NLKLLDLSGN
   181  NLTHLPKGLL GAQAKLERLL LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR
   241  LPNLSSLTLS RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT
   301  QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG LTALPDGLLR
   361  GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE TLPGDVFGAL PRLTEVLLGH
   421  NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR CAGPGAHAGL PLWALPGGDA ECPGPRGPPP
   481  RPAADSSSEA PVHPALAPNS SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV
   541  FAMIKIGQLF RKLIRERALG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

lymph node: 1 nTPM
appendix: 0.6 nTPM
fallopian tube: 0.6 nTPM
bone marrow: 0.5 nTPM
tonsil: 0.5 nTPM
spleen: 0.4 nTPM

Single-cell type

platelets: 25 nCPM
megakaryocytes: 19 nCPM
thymocytes: 3.4 nCPM
fallopian tube ciliated cells: 2 nCPM
ependymal cells: 1.8 nCPM
megakaryocyte progenitors: 1.7 nCPM

Immune cell

naive CD8 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

midbrain: 0.6 nTPM
cerebral cortex: 0.5 nTPM
hypothalamus: 0.5 nTPM
medulla oblongata: 0.5 nTPM
spinal cord: 0.5 nTPM
cerebellum: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GP5 as an antibody target. Whether an autoantibody or antibody against GP5 could matter depends on whether native GP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GP5 is annotated at the cell surface, where native GP5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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