Seroatlas · Human Serome Atlas

LRIG1

Leucine-rich repeats and immunoglobulin-like domains protein 1

Also known as: DKFZP586O1624, LIG-1, LIG1, LRIG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JA1
Gene: LRIG1
Ensembl: ENSG00000144749
Chromosome: 3
Canonical length: 1093 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1093 residues, UniProt reviewed canonical sequence.

>Q96JA1|LRIG1
     1  MARPVRGGLG APRRSPCLLL LWLLLLRLEP VTAAAGPRAP CAAACTCAGD SLDCGGRGLA
    61  ALPGDLPSWT RSLNLSYNKL SEIDPAGFED LPNLQEVYLN NNELTAVPSL GAASSHVVSL
   121  FLQHNKIRSV EGSQLKAYLS LEVLDLSLNN ITEVRNTCFP HGPPIKELNL AGNRIGTLEL
   181  GAFDGLSRSL LTLRLSKNRI TQLPVRAFKL PRLTQLDLNR NRIRLIEGLT FQGLNSLEVL
   241  KLQRNNISKL TDGAFWGLSK MHVLHLEYNS LVEVNSGSLY GLTALHQLHL SNNSIARIHR
   301  KGWSFCQKLH ELVLSFNNLT RLDEESLAEL SSLSVLRLSH NSISHIAEGA FKGLRSLRVL
   361  DLDHNEISGT IEDTSGAFSG LDSLSKLTLF GNKIKSVAKR AFSGLEGLEH LNLGGNAIRS
   421  VQFDAFVKMK NLKELHISSD SFLCDCQLKW LPPWLIGRML QAFVTATCAH PESLKGQSIF
   481  SVPPESFVCD DFLKPQIITQ PETTMAMVGK DIRFTCSAAS SSSSPMTFAW KKDNEVLTNA
   541  DMENFVHVHA QDGEVMEYTT ILHLRQVTFG HEGRYQCVIT NHFGSTYSHK ARLTVNVLPS
   601  FTKTPHDITI RTTTMARLEC AATGHPNPQI AWQKDGGTDF PAARERRMHV MPDDDVFFIT
   661  DVKIDDAGVY SCTAQNSAGS ISANATLTVL ETPSLVVPLE DRVVSVGETV ALQCKATGNP
   721  PPRITWFKGD RPLSLTERHH LTPDNQLLVV QNVVAEDAGR YTCEMSNTLG TERAHSQLSV
   781  LPAAGCRKDG TTVGIFTIAV VSSIVLTSLV WVCIIYQTRK KSEEYSVTNT DETVVPPDVP
   841  SYLSSQGTLS DRQETVVRTE GGPQANGHIE SNGVCPRDAS HFPEPDTHSV ACRQPKLCAG
   901  SAYHKEPWKA MEKAEGTPGP HKMEHGGRVV CSDCNTEVDC YSRGQAFHPQ PVSRDSAQPS
   961  APNGPEPGGS DQEHSPHHQC SRTAAGSCPE CQGSLYPSNH DRMLTAVKKK PMASLDGKGD
  1021  SSWTLARLYH PDSTELQPAS SLTSGSPERA EAQYLLVSNG HLPKACDASP ESTPLTGQLP
  1081  GKQRVPLLLA PKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRIG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 136 nTPM

Expression across tissuesHPA

Tissue

pancreas: 136 nTPM
cerebral cortex: 61 nTPM
skeletal muscle: 35 nTPM
heart muscle: 35 nTPM
stomach: 34 nTPM
colon: 33 nTPM

Single-cell type

astrocytes: 586 nCPM
pituitary stem cells: 460 nCPM
bergmann glia: 324 nCPM
pancreatic acinar cells: 284 nCPM
adipocytes: 240 nCPM
respiratory basal cells: 240 nCPM

Immune cell

T-reg: 1.1 nTPM
MAIT T-cell: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
eosinophil: 0.3 nTPM

Brain region

thalamus: 148 nTPM
midbrain: 119 nTPM
amygdala: 108 nTPM
medulla oblongata: 101 nTPM
basal ganglia: 98 nTPM
hypothalamus: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.04
gnomAD missense Z: -1.18
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRIG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRIG1 as an antibody target. Whether an autoantibody or antibody against LRIG1 could matter depends on whether native LRIG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRIG1 is annotated at the cell surface, where native LRIG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRIG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...