Seroatlas · Human Serome Atlas

LRG1

Leucine-rich alpha-2-glycoprotein

Also known as: A2GL_HUMAN, LRG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P02750
Gene: LRG1
Ensembl: ENSG00000171236
Chromosome: 19
Canonical length: 347 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>P02750|LRG1
     1  MSSWSRQRPK SPGGIQPHVS RTLFLLLLLA ASAWGVTLSP KDCQVFRSDH GSSISCQPPA
    61  EIPGYLPADT VHLAVEFFNL THLPANLLQG ASKLQELHLS SNGLESLSPE FLRPVPQLRV
   121  LDLTRNALTG LPPGLFQASA TLDTLVLKEN QLEVLEVSWL HGLKALGHLD LSGNRLRKLP
   181  PGLLANFTLL RTLDLGENQL ETLPPDLLRG PLQLERLHLE GNKLQVLGKD LLLPQPDLRY
   241  LFLNGNKLAR VAAGAFQGLR QLDMLDLSNN SLASVPEGLW ASLGQPNWDM RDGFDISGNP
   301  WICDQNLSDL YRWLQAQKDK MFSQNDTRCA GPEAVKGQTL LAVAKSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1,004 nTPM

Expression across tissuesHPA

Tissue

liver: 1,004 nTPM
pancreas: 51 nTPM
bone marrow: 30 nTPM
esophagus: 24 nTPM
salivary gland: 20 nTPM
spleen: 18 nTPM

Single-cell type

fallopian tube ciliated cells: 6.2 nCPM
neutrophils: 5.9 nCPM
hepatocytes: 3.8 nCPM
endometrial secretory cells: 1.9 nCPM
fallopian secretory cells: 1.6 nCPM
pancreatic duct cells: 1.4 nCPM

Immune cell

neutrophil: 285 nTPM
eosinophil: 15 nTPM
classical monocyte: 6.3 nTPM
basophil: 2.2 nTPM
total PBMC: 2.2 nTPM
intermediate monocyte: 2 nTPM

Brain region

cerebral cortex: 7 nTPM
pons: 5.3 nTPM
cerebellum: 3.7 nTPM
choroid plexus: 3.6 nTPM
thalamus: 3.2 nTPM
white matter: 2.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRG1.

Disease | ImmuneIEDB

Conditions an epitope on LRG1 was assayed in.

rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.1
gnomAD missense Z: -0.05
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRG1 as an antibody target. Whether an autoantibody or antibody against LRG1 could matter depends on whether native LRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRG1 is annotated as secreted, so native LRG1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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