Seroatlas · Human Serome Atlas

LRIT1

Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1

Also known as: DKFZP434K091, FIGLER9, LRIT1_HUMAN, LRRC21, PAL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2V4
Gene: LRIT1
Ensembl: ENSG00000148602
Chromosome: 10
Canonical length: 623 aa
Protein class: Predicted membrane proteins
Subcellular location: Flagellar centriole
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to act upstream of or within phototransduction; synaptic signaling; and visual perception. Predicted to be located in dendrite; endoplasmic reticulum; and membrane. Predicted to be active in endoplasmic reticulum membrane; synapse; and synaptic cleft. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

623 residues, UniProt reviewed canonical sequence.

>Q9P2V4|LRIT1
     1  MRVALGMLWL LALAWPPQAR GFCPSQCSCS LHIMGDGSKA RTVVCNDPDM TLPPASIPPD
    61  TSRLRLERTA IRRVPGEAFR PLGRLEQLWL PYNALSELNA LMLRGLRRLR ELRLPGNRLA
   121  AFPWAALRDA PKLRLLDLQA NRLSAVPAEA ARFLENLTFL DLSSNQLMRL PQELIVSWAH
   181  LETGIFPPGH HPRRVLGLQD NPWACDCRLY DLVHLLDGWA PNLAFIETEL RCASPRSLAG
   241  VAFSQLELRK CQGPELHPGV ASIRSLLGGT ALLRCGATGV PGPEMSWRRA NGRPLNGTVH
   301  QEVSSDGTSW TLLGLPAVSH LDSGDYICQA KNFLGASETV ISLIVTEPPT STEHSGSPGA
   361  LWARTGGGGE AAAYNNKLVA RHVPQIPKPA VLATGPSVPS TKEELTLEHF QMDALGELSD
   421  GRAGPSEARM VRSVKVVGDT YHSVSLVWKA PQAKNTTAFS VLYAVFGQHS MRRVIVQPGK
   481  TRVTITGLLP KTKYVACVCV QGLVPRKEQC VIFSTNEVVD AENTQQLINV VVISVAIVIA
   541  LPLTLLVCCS ALQKRCRKCF NKDSTEATVT YVNLERLGYS EDGLEELSRH SVSEADRLLS
   601  ARSSVDFQAF GVKGGRRINE YFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRIT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

retina: 24 nTPM
testis: 5.5 nTPM
choroid plexus: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late spermatids: 53 nCPM
late primary spermatocytes: 44 nCPM
early spermatids: 25 nCPM
retinal bipolar cells: 14 nCPM
cone photoreceptor cells: 8.3 nCPM
müller glia: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.5 nTPM
hypothalamus: 0.9 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
midbrain: 0.3 nTPM
thalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRIT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LRIT2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRIT1 as an antibody target. Whether an autoantibody or antibody against LRIT1 could matter depends on whether native LRIT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRIT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRIT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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