Seroatlas · Human Serome Atlas

LINGO4

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

Also known as: LIGO4_HUMAN, LRRN6D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UY18
Gene: LINGO4
Ensembl: ENSG00000213171
Chromosome: 1
Canonical length: 593 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q6UY18|LINGO4
     1  MDAATAPKQA WPPWPPLLFL LLLPGGSGGS CPAVCDCTSQ PQAVLCGHRQ LEAVPGGLPL
    61  DTELLDLSGN RLWGLQQGML SRLSLLQELD LSYNQLSTLE PGAFHGLQSL LTLRLQGNRL
   121  RIMGPGVFSG LSALTLLDLR LNQIVLFLDG AFGELGSLQK LEVGDNHLVF VAPGAFAGLA
   181  KLSTLTLERC NLSTVPGLAL ARLPALVALR LRELDIGRLP AGALRGLGQL KELEIHLWPS
   241  LEALDPGSLV GLNLSSLAIT RCNLSSVPFQ ALYHLSFLRV LDLSQNPISA IPARRLSPLV
   301  RLQELRLSGA CLTSIAAHAF HGLTAFHLLD VADNALQTLE ETAFPSPDKL VTLRLSGNPL
   361  TCDCRLLWLL RLRRHLDFGM SPPACAGPHH VQGKSLKEFS DILPPGHFTC KPALIRKSGP
   421  RWVIAEEGGH AVFSCSGDGD PAPTVSWMRP HGAWLGRAGR VRVLEDGTLE IRSVQLRDRG
   481  AYVCVVSNVA GNDSLRTWLE VIQVEPPNGT LSDPNITVPG IPGPFFLDSR GVAMVLAVGF
   541  LPFLTSVTLC FGLIALWSKG KGRVKHHMTF DFVAPRPSGD KNSGGNRVTA KLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINGO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 23 nTPM
cerebellum: 6.3 nTPM
tongue: 5.2 nTPM
adrenal gland: 1.9 nTPM
pituitary gland: 1.6 nTPM
liver: 1.3 nTPM

Single-cell type

adrenal medulla cells: 11 nCPM
innate lymphoid cells: 6.2 nCPM
myonuclei: 3.6 nCPM
epicardial cells: 2.3 nCPM
fallopian tube ciliated cells: 1.7 nCPM
renal collecting duct intercalated cells: 1.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 9 nTPM
pons: 8.7 nTPM
medulla oblongata: 6.3 nTPM
white matter: 4.6 nTPM
midbrain: 3.8 nTPM
thalamus: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINGO4 as an antibody target. Whether an autoantibody or antibody against LINGO4 could matter depends on whether native LINGO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINGO4 is annotated at the cell surface, where native LINGO4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LINGO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...