Seroatlas · Human Serome Atlas

LRIT2

Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2

Also known as: AC022389.4, LRIT2_HUMAN, LRRC22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDA9
Gene: LRIT2
Ensembl: ENSG00000204033
Chromosome: 10
Canonical length: 550 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>A6NDA9|LRIT2
     1  MASVFHYFLL VLVFLDTHAA QPFCLPGCTC SEESFGRTLQ CTSVSLGKIP GNLSEEFKQV
    61  RIENSPLFEM PQGSFINMST LEYLWLNFNN ISVIHLGALE HLPELRELRL EGNKLCSVPW
   121  TAFRATPLLR VLDLKRNKID ALPELALQFL VSLTYLDLSS NRLTVVSKSV FLNWPAYQKC
   181  RQPDCGAEIL SSLVVALHDN PWVCDCRLRG LVQFVKSITL PVILVNSYLI CQGPLSKAGQ
   241  LFHETELSAC MKPQISTPSA NITIRAGQNV TLRCLAQASP SPSIAWTYPL SMWREFDVLT
   301  SSTGEDTALS ELAIPAAHLV DSGNYTCMAS NSIGKSNLVI SLHVQPAQAL HAPDSLSIPS
   361  EGNAYIDLRV VKQTVHGILL EWLAVADTSK EEWFTLYIAS DEAFRKEVVH IGPGINTYAV
   421  DDLLPGTKYE ACLSLEGQPP HQGQCVAFVT GRDAGGLEAR EHLLHVTVVL CVVLLAVPVG
   481  AYAWAAQGPC SCSKWVLRGC LHRRKAPSCT PAAPQSKDGS FREHPAVCDD GEGHIDTEGD
   541  KEKGGTEDNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRIT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

retina: 55 nTPM
skin: 2.7 nTPM
basal ganglia: 1.5 nTPM
colon: 1 nTPM
cerebral cortex: 0.5 nTPM
small intestine: 0.4 nTPM

Single-cell type

rod photoreceptor cells: 31 nCPM
retinal pigment epithelial cells: 13 nCPM
retinal bipolar cells: 9.7 nCPM
cone photoreceptor cells: 4.1 nCPM
retinal ganglion cells: 3.9 nCPM
late spermatids: 2.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.3 nTPM
basal ganglia: 0.9 nTPM
pons: 0.6 nTPM
hypothalamus: 0.5 nTPM
medulla oblongata: 0.5 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -1.75
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRIT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LRIT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRIT2 as an antibody target. Whether an autoantibody or antibody against LRIT2 could matter depends on whether native LRIT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRIT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRIT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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