Seroatlas · Human Serome Atlas

LRRN1

Leucine-rich repeat neuronal protein 1

Also known as: FIGLER3, LRRN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXK5
Gene
LRRN1
Ensembl
ENSG00000175928
Chromosome
3
Canonical length
716 aa
Protein class
Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus,Centriolar satellite,Basal body

OverviewNCBI Gene

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q6UXK5|LRRN1
     1  MARMSFVIAA CQLVLGLLMT SLTESSIQNS ECPQLCVCEI RPWFTPQSTY REATTVDCND
    61  LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL DFSQNNFTNI KEVGLANLTQ
   121  LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI NHNQISTISA HAFAGLKNLL RLHLNSNKLK
   181  VIDSRWFDST PNLEILMIGE NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS
   241  LESLSFYDNK LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
   301  VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN AIYQKTVESL
   361  PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA MPPEYKGHQV KEVLIQDSSE
   421  QCLPMISHDS FPNRLNVDIG TTVFLDCRAM AEPEPEIYWV TPIGNKITVE TLSDKYKLSS
   481  EGTLEISNIQ IEDSGRYTCV AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL
   541  VSWKVNSNVM TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
   601  IHQQTQKSCV NVTTKNAAFA VDISDQETST ALAAVMGSMF AVISLASIAV YFAKRFKRKN
   661  YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGSA DTKPTQVDTS RSYYMW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 16 nTPM
  • basal ganglia: 9.2 nTPM
  • amygdala: 6.7 nTPM
  • hippocampal formation: 6 nTPM
  • testis: 5.6 nTPM
  • skeletal muscle: 5.4 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 550 nCPM
  • brain inhibitory neurons: 157 nCPM
  • ependymal cells: 131 nCPM
  • pituitary stem cells: 113 nCPM
  • sertoli cells: 106 nCPM
  • astrocytes: 81 nCPM

Immune cell

  • neutrophil: 0.4 nTPM
  • eosinophil: 0.3 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 45 nTPM
  • midbrain: 37 nTPM
  • medulla oblongata: 36 nTPM
  • pons: 35 nTPM
  • basal ganglia: 34 nTPM
  • amygdala: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
0.35
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRN1 as an antibody target. Whether an autoantibody or antibody against LRRN1 could matter depends on whether native LRRN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRN1 is annotated at the cell surface, where native LRRN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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