G-protein coupled receptor 2
IPR050332
Definition
The G-protein coupled receptor 2 family is characterized by its involvement in diverse physiological processes through the binding of various peptide ligands, such as hormones and neuropeptides. Members of this family play pivotal roles in the regulation of metabolic pathways, stress responses, and developmental processes. They are typically composed of seven transmembrane helices and are coupled to G proteins, which activate adenylyl cyclase, leading to increased intracellular cAMP levels. Some receptors also couple to phospholipase C or inhibit calcium channels. Functions of these receptors include regulation of blood glucose levels, hormone secretion, smooth muscle relaxation, and modulation of neurotransmission and circadian rhythms. The specificity and diversity of ligand binding, along with the downstream signaling mechanisms, underscore the family's importance in maintaining homeostasis and responding to physiological changes.
15 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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