Seroatlas · Human Serome Atlas

HECTD4

Probable E3 ubiquitin-protein ligase HECTD4

Also known as: HECD4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4D8
Gene: HECTD4
Canonical length: 3996 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for HECTD4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

3996 residues, UniProt reviewed canonical sequence.

>Q9Y4D8|HECTD4
     1  MPANHLPIGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL VVENGVFVAN
    61  PLQERTILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA LTGSTISNTL KEDQAANTSC
   121  GLPLKMLRKT PIYTCGTYLV MLVPPPGGSG SSATRSLFGG TSGLSSLKRA CYDTVNNMLW
   181  TCSNDYIDQW CNPGNQAFHY VCQRLGVSHI ITEPKEEAIT TNEVINQLLH HVGAMCIHQL
   241  NLLATNPNLP ITSVLGKQHP IEAHHLSSIC DIMEKAMVNG DTCIIRCILV VFQVVFKFFF
   301  SPQTERNRDI IRRSGLLLWQ LLMAPKDQIC PEIQKEVCLA ISSGLNILYP GETEINNLLK
   361  LVLTEGERNS GLSQLRDVIL TNLAEQLQNN RFGSDEDDHY RLNDELLHYI LKIVVRESCI
   421  LITKCQTVSK DDFQKLLSTV PAASSCLRYL MAVQNHLLSN TILIKPDEND DSDSSLQGET
   481  LKVQELKVSI LALATQILTG CDEVLEMLQQ VTTALINSDI ADREQRLKGL EQVTKATMLG
   541  HLLPVLLTSL MHPNLQTLIM ADALMPQLVQ LVLYTSQTAL LLKTQCPVFA EVGCSPCGAP
   601  DQKCRLFPDE RMLEEKEEPG FLTGLKIPAP WAAGKTVETV HPVRDNYKFK ETVHIPGARC
   661  LYLRFDSRCS SQYDYDKLVI YAGPNTNSRK VAEYGGNTLG YGSRSVLGTG WPKDLVKCIS
   721  PPSLNFKVEG DTVTFSFEMR SGREHNTPDK AMWGFACTVR AQESSEDVSG GLPFLVDLAL
   781  GLSVLACSML RILYNGPEIT KEEEACQELL RSKLLQRCQW QVEANGVISP ALTPSPSPLP
   841  LTIEEDREFT YPSDVLVPPV GNYFDLPRIR LPPGIMIKLR EISGRARPQF RPSIKEVIQP
   901  DVMEEMVVSC VIKHLNLVDA LQSLINFQYQ EEHAEEYDLL CKIMGETFKK LNAMERQLQS
   961  VAELEQKWQS EVDDAMQGKL ENNMPFFYDY HFNENKMKEL ELLCSMKEVS FDGNDLENMV
  1021  LSLREKFLQE VNSLIQKPSH PLAKTKTLVK SLMNRAELLL HVTIAAQSGL TRSISGTPAE
  1081  TPACKSASET KVISHAVRQP VFLRSMSAPS DLEMIGNEDL EFTRANQRRR HVTSHRSSSF
  1141  TLLQSLAIED SRDKPTYSVL LGQLFAFIGT NPDQAVSSSS FLLAAQTRWR RGNTRKQALV
  1201  HMRELLTAAV RVGGVTHLVG PVTMVLQGGP RIEELTCGGM VEQVQEAFGE TMTSVVSLCA
  1261  RYPIACANSI GLLCTIPYTR SEEKCLVRSG LVQLMDRLCS LSNQTESSSS EKQTKKQKVA
  1321  TMAWAAFQVL ANRCVEWEKE EGGSTEAVHS GLARQVSSLL TNHLARATEC CGNQAAGNDA
  1381  LQDVLSLLND LSRSHIGKAI LSQPACVSKL LSLLLDQRPS PKLVLIILQL CRAALPLMSV
  1441  EDCGNVELPP WSYSVPSLNS EQEDPSDPAS KIASLLLAKL ADYVVPGCQT VLSPTASEPD
  1501  TTLTKTSPKN SLKGDKDPGE ESEAVDGKLS IFIHKREDQS SHEVLQPLLS SSEGRPFRLG
  1561  TGANMEKVVK MDRDMTKGGC CEVITEEAAA ALRKATKWAQ SGLIVSIGPP VESINPETVS
  1621  GLSTGDKKKT AQTSICRERN SELARTDPVR PFISGHVANS MAAEVIALLH SLLMAPESNA
  1681  AQIWTTTAEK VLSRALMYIP QLGKYAESIL ENGSSSGRKL AKLQRIARQA VAALCALGGF
  1741  KETIKIGSEV QVLGRGISGS IGVVASINEQ EGIATVRFPP IDCRKTSQAS DTLTIPLSRL
  1801  CVPRSEALPL HKLSITEKVV QAVQSMLLPQ EGSLSIHTSL PATGDGSAPV MAVVRLLAEI
  1861  RTRACLVMAQ LLEDSLFCEE FIQQCPAAVE VLNLVAQECS AGERLAVVEV QCERLRMLYR
  1921  DCARPPPPPL QADRRQPKEI TWSPSRVFPP VRACMFSSHL TSVTFLADPS AGGGLPRGTF
  1981  IYATSPLPVQ APSFYWEIEI VSYGDTDDDT GPIVSFGFTT EAEKRDGAWT NPVGTCLFHN
  2041  NGRAVHYNGS SLLQWKSVRL DVTLSPGDVA GIGWERTEGT PPPPGQPAKG RVYFTYCGQR
  2101  LSPYLEDVSG GMWPVVHIQK KNTKTRANFG SRPFAYAEGQ AHRNAADLCT DLAEEISANF
  2161  EALPFAMASD SDNDAGTSIA SDPGTHGPPC RIAAVATAQQ QYDSDTSCHY KVELSYENFI
  2221  TSGPDPHPPP IADDESDDDD DDDIPQEDHY ALLVKAWETK VFPTIRRRFR NEAERKSGLD
  2281  QIKGALQLGM VDIARQTVEF LYEENGGIPR DLYLPTIEDI KDEANKFTID KVRKGLTVVT
  2341  RSPDSNNVAS SAVGTALPKF AIRGMLKTFG LHGVVLDVDS VNELVQVETY LRSEGVLVRY
  2401  WYPIDMLERP PAGYRRTATN GLVTLDNTNL QIHRELLRCE AALARLYCRM ALLNIFAPKL
  2461  PHLFTRLFHI PAIRDITLEH LQLLSNQLLA PPLPDGTISS SSILLAQSLQ HCIHSQNCSA
  2521  TDLFYQGNSQ TVREWLNVAI TRTLHQGEES LLELTKQICS FLQTAPEQFP SEEFPISESK
  2581  VNMDVNFPGA AFVVVSCKES QSGFRKDSSL YKAPWARVLV YGLGHKVKRN GQLNLIEAAC
  2641  YPRDASPANT GLAPPPTADQ YPSVVLSTDR VHIKLGVSPP PGAVLVLHSL PLEFPLAMAF
  2701  AEQLLSWKSE DSEGKSEDEP DTIPTSVLLQ VVELLGNFLW TTDMAACVKE LVFHLLAELL
  2761  RTVHTLEQRR HPAGLSSSIA LQLNPCLAML MALQSELHKL YDEETQNWVS GGACGGSGGA
  2821  AAGDQGRFST YFHALMEGCL AVAEVTLPTN MSVTASGVTS ATAPNLSDSS SSSSSSPGQT
  2881  PQSPSLLSKR KKVKMKREKA SSSGKRQSSR TVDSDPTVLS IGGSKPEDML WFHRALTLLI
  2941  ILRHLTRKDP QGLGVTSDAI ADACQALVGP TAHSRLLVIS GIPTHLDEGV VRGAIRKACN
  3001  AHGGVFKDEI YIPLQEEDTK KPKDKAEGGD GKVEPEKTLA FPGTDSMEVS TSSSLTPAMS
  3061  ISASASTSQA SICSSQGISQ TVSDLSVDPL PAGLELPIPP GLLEPHAVSS QESLDISLCS
  3121  TGSLGSLGSL GEPLDNAETA SVSDMGSMYT VTSLDNQPLA ARPIKGFAVV EIRSRAKIEK
  3181  IRASLFNNND LIGLSSLDGE DELMEMSTEE ILTVSVVNQS LFDTQGSPGL EDYFNDKSIK
  3241  GEKLVPGARE VLTEIFKSCA HSEQTLSLTP AKPIRVSDIY LSKEQINSQT PGNLLHLFFT
  3301  NVRPPKKVLE DQLTQILRKY GVPKPKFDKS KYSKAGKEQH PVKVVSTKRP ITKPPAKDKA
  3361  VLNSVSRTAL SEKKPTVKPK SPEKSKPDEK DPEKSPTKKQ EVPEEKYLTL EGFHKFVIDR
  3421  ARQDIRSVWR AILSCGYDLH FERCACIDVR HAQKASRKWT LEMDVALVQY INQLCRHLAI
  3481  TPARLHPHEV YLDPADAADP RVACLLNVPI ESLRLRFALL QSLNTTLETF FLPLVELRQT
  3541  PMYTHSIAAL LKEAKGLIFY DTKVTVMNRV LNATVQRTAD HAAPEITLDP LEIVGGEIRA
  3601  SENSYFCQAA RQLASVPSSQ LCVKLASGGD PTYAFNIRFT GEEVHGTSGS FRHFLWQVCK
  3661  ELQSSSLSLL LLCPSSAVNK NKGKYILTPS PITYGEEQLL HFLGQLLGIA IRADVPLPLD
  3721  LLPSFWKTLV GEPLDPEQDL QEADILTYNY VKKFESINDE TELEALCAEI ASQHLATESP
  3781  DSPNKPCCRF TYLTMTGEEV ELCSRGRHIL VAWENKDIYA AAIRSLRLRE LQNVECVTAV
  3841  RAGLGSIIPL QLLTMLSPLE MELRTCGLPY INLEFLKAHT MYQVGLMETD QHIEFFWGAL
  3901  EMFTQEELCK FIKFACNQER IPFTCPCKDG GPDTAHVPPY PMKIAPPDGT AGSPDSRYIR
  3961  VETCMFMIKL PQYSSLEIML EKLRCAIHYR EDPLSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HECTD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 14 nTPM
bone marrow: 13 nTPM
retina: 10 nTPM
cerebral cortex: 7.9 nTPM
thyroid gland: 6.8 nTPM
thymus: 6 nTPM

Single-cell type

choroid plexus epithelial cells: 532 nCPM
myonuclei: 450 nCPM
retinal ganglion cells: 363 nCPM
cone photoreceptor cells: 358 nCPM
brain excitatory neurons: 345 nCPM
somatotrophs: 342 nCPM

Immune cell

naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
basophil: 0.2 nTPM
gdT-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM

Brain region

cerebellum: 97 nTPM
cerebral cortex: 78 nTPM
basal ganglia: 77 nTPM
white matter: 77 nTPM
hippocampal formation: 69 nTPM
hypothalamus: 69 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HECTD4.

Disease | AllUniProt

Conditions HECTD4 is implicated in, by any mechanism.

Neurodevelopmental disorder with seizures, spasticity, and complete or partial agenesis of the corpus callosum (NEDSSCC) MIM:620250

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 582 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with seizures, spasticity, and complete or partial agenesis of the corpus callosum
See cases
Autism spectrum disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 6.94

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HECTD4 as an antibody target. Whether an autoantibody or antibody against HECTD4 could matter depends on whether native HECTD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HECTD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HECTD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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