Seroatlas · Human Serome Atlas

HECTD2

Probable E3 ubiquitin-protein ligase HECTD2

Also known as: FLJ37306, HECD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5U5R9
Gene
HECTD2
Ensembl
ENSG00000165338
Chromosome
10
Canonical length
776 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

776 residues, UniProt reviewed canonical sequence.

>Q5U5R9|HECTD2
     1  MSEAVRVPSP ATPLVVAAPA PEERKGKESE REKLPPIVSA GAGATAGLDR GAKGQISTFS
    61  SFISAVSPKK EAAENRSSPA HLVFPNIKNV REPPPICLDV RQKQRTSMDA SSSEMKAPVL
   121  PEPILPIQPK TVKDFQEDVE KVKSSGDWKA VHDFYLTTFD SFPELNAAFK KDATASFNTI
   181  EDSGINAKFV NAVYDTLLNT PQDVQKTVLK GIINSLLREW KGPRTKDDLR AYFILLQNPQ
   241  FNNTSTYVIY AHLLRQIATL VEADHHFLVH WFKKLSQKRF KQLVERLLQF ISLRLFPAKP
   301  EEFPPITKCS WWIPSAAKVL ALLNTANNLV HPPLIPYTDF YNSTLDHIDL MEEYHTWQNF
   361  GNSHRFSFCQ YPFVISVAAK KIIIQRDSEQ QMINIARQSL VDKVSRRQRP DMNILFLNMK
   421  VRRTHLVSDS LDELTRKRAD LKKKLKVTFV GEAGLDMGGL TKEWFLLLIR QIFHPDYGMF
   481  TYHKDSHCHW FSSFKCDNYS EFRLVGILMG LAVYNSITLD IRFPPCCYKK LLSPPIIPSD
   541  QNIPVGICNV TVDDLCQIMP ELAHGLSELL SHEGNVEEDF YSTFQVFQEE FGIIKSYNLK
   601  PGGDKISVTN QNRKEYVQLY TDFLLNKSIY KQFAAFYYGF HSVCASNALM LLRPEEVEIL
   661  VCGSPDLDMH ALQRSTQYDG YAKTDLTIKY FWDVVLGFPL DLQKKLLHFT TGSDRVPVGG
   721  MADLNFKISK NETSTNCLPV AHTCFNQLCL PPYKSKKDLK QKLIIGISNS EGFGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HECTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 16 nTPM
  • seminal vesicle: 16 nTPM
  • blood vessel: 12 nTPM
  • smooth muscle: 12 nTPM
  • endometrium: 11 nTPM
  • cerebral cortex: 11 nTPM

Single-cell type

  • myonuclei: 294 nCPM
  • papillary tip epithelial cells: 175 nCPM
  • microglia: 167 nCPM
  • brain inhibitory neurons: 145 nCPM
  • brain excitatory neurons: 109 nCPM
  • podocytes: 101 nCPM

Immune cell

  • NK-cell: 2.9 nTPM
  • basophil: 0.6 nTPM
  • gdT-cell: 0.4 nTPM
  • intermediate monocyte: 0.4 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • cerebellum: 27 nTPM
  • basal ganglia: 25 nTPM
  • amygdala: 23 nTPM
  • white matter: 23 nTPM
  • hippocampal formation: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
4.11
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HECTD2 as an antibody target. Whether an autoantibody or antibody against HECTD2 could matter depends on whether native HECTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HECTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HECTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HECTD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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