Seroatlas · Human Serome Atlas

AREL1

Apoptosis-resistant E3 ubiquitin protein ligase 1

Also known as: AREL1_HUMAN, FIEL1, KIAA0317

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15033
Gene: AREL1
Ensembl: ENSG00000119682
Chromosome: 14
Canonical length: 823 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in negative regulation of apoptotic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>O15033|AREL1
     1  MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC
    61  KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE
   121  PNSNVVKVAF TVRKAGRYEI TVKLGGLNVA YSPYYKIFQP GMVVPSKTKI VCHFSTLVLT
   181  CGQPHTLQIV PRDEYDNPTN NSMSLRDEHN YTLSIHELGP QEEESTGVSF EKSVTSNRQT
   241  FQVFLRLTLH SRGCFHACIS YQNQPINNGE FDIIVLSEDE KNIVERNVST SGVSIYFEAY
   301  LYNATNCSST PWHLPPMHMT SSQRRPSTAV DEEDEDSPSE CHTPEKVKKP KKVYCYVSPK
   361  QFSVKEFYLK IIPWRLYTFR VCPGTKFSYL GPDPVHKLLT LVVDDGIQPP VELSCKERNI
   421  LAATFIRSLH KNIGGSETFQ DKVNFFQREL RQVHMKRPHS KVTLKVSRHA LLESSLKATR
   481  NFSISDWSKN FEVVFQDEEA LDWGGPRREW FELICKALFD TTNQLFTRFS DNNQALVHPN
   541  PNRPAHLRLK MYEFAGRLVG KCLYESSLGG AYKQLVRARF TRSFLAQIIG LRMHYKYFET
   601  DDPEFYKSKV CFILNNDMSE MELVFAEEKY NKSGQLDKVV ELMTGGAQTP VTNANKIFYL
   661  NLLAQYRLAS QVKEEVEHFL KGLNELVPEN LLAIFDENEL ELLMCGTGDI SVSDFKAHAV
   721  VVGGSWHFRE KVMRWFWTVV SSLTQEELAR LLQFTTGSSQ LPPGGFAALC PSFQIIAAPT
   781  HSTLPTAHTC FNQLCLPTYD SYEEVHRMLQ LAISEGCEGF GML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AREL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
testis: 16 nTPM
parathyroid gland: 15 nTPM
thyroid gland: 15 nTPM
kidney: 14 nTPM
retina: 13 nTPM

Single-cell type

neutrophils: 439 nCPM
neutrophil progenitors: 145 nCPM
erythrocyte progenitors: 91 nCPM
monocytes: 69 nCPM
sertoli cells: 63 nCPM
renal collecting duct intercalated cells: 62 nCPM

Immune cell

neutrophil: 7.3 nTPM
eosinophil: 7.2 nTPM
intermediate monocyte: 5.1 nTPM
gdT-cell: 4.7 nTPM
myeloid DC: 4.5 nTPM
memory CD8 T-cell: 4.3 nTPM

Brain region

hippocampal formation: 20 nTPM
thalamus: 18 nTPM
cerebral cortex: 17 nTPM
hypothalamus: 16 nTPM
basal ganglia: 16 nTPM
amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

HECT domain
Immunoglobulin-like fold
Immunoglobulin E-set
Filamin/ABP280 repeat-like
HECT, E3 ligase catalytic domain
E3 ubiquitin-protein ligase
Filamin/ABP280 repeat
HECT-domain (ubiquitin-transferase)
Apoptosis-resistant E3 ubiquitin protein ligase 1, PH-like domain
Apoptosis-resistant E3 ubiquitin protein ligase 1, N-terminal domain
AREL1 N-terminal domain
AREL1 PH-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AREL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AREL1 as an antibody target. Whether an autoantibody or antibody against AREL1 could matter depends on whether native AREL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AREL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AREL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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