Reprolysin domain, adamalysin-type
IPR034027
Definition
This entry includes the reprolysin-like domain found in snake venom metallopeptidases such as adamalysin PMID:9521103 and membrane-anchored metalloendopeptidases known as ADAMs (A Disintegrin And Metalloprotease), which are glycoproteins and play roles in cell signaling, cell fusion, and cell-cell interactions [[cite:PMID:10652535], [cite:PMID:9818177], [cite:PMID:7593158]]. Peptidase activity depends on the presence of an extended zinc-binding motif known as HEXXHXXGXXH in which the histidines are zinc ligands, the glutamic acid is a catalytic residue and the glycine maintains an important turn. There are a number of proteins in which one or more of these essential residues are not conserved, and these do not have proteolytic activity.
19 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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