ETFB

Protein identityUniProt · HPA

UniProt accession

P38117

Gene

ETFB

Ensembl

ENSG00000105379

Chromosome

19

Canonical length

255 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>P38117|ETFB
     1  MAELRVLVAV KRVIDYAVKI RVKPDRTGVV TDGVKHSMNP FCEIAVEEAV RLKEKKLVKE
    61  VIAVSCGPAQ CQETIRTALA MGADRGIHVE VPPAEAERLG PLQVARVLAK LAEKEKVDLV
   121  LLGKQAIDDD CNQTGQMTAG FLDWPQGTFA SQVTLEGDKL KVEREIDGGL ETLRLKLPAV
   181  VTADLRLNEP RYATLPNIMK AKKKKIEVIK PGDLGVDLTS KLSVISVEDP PQRTAGVKVE
   241  TTEDLVAKLK EIGRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETFB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

490 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ETFB.

Disease | AllUniProt

Conditions ETFB is implicated in, by any mechanism.

• Glutaric aciduria 2B (GA2B) MIM:231680

Disease | GeneticClinVar

39 pathogenic / likely-pathogenic of 398 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Multiple acyl-CoA dehydrogenase deficiency
• Glutaric acidemia IIb

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.83

gnomAD pLI

0.02

gnomAD missense Z

0.42

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amino acid catabolic process
• fatty acid beta-oxidation using acyl-CoA dehydrogenase
• respiratory electron transport chain

Molecular functions

• electron transfer activity

Cellular components

• electron transfer flavoprotein complex
• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Rossmann-like alpha/beta/alpha sandwich fold
• Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
• Electron transfer flavoprotein domain
• Electron transfer flavoprotein, beta-subunit, conserved site
• Electron transfer flavoprotein, beta subunit
• Electron transfer flavoprotein, beta subunit, N-terminal

KeywordsUniProt

• Acetylation
• Electron transport
• Glutaricaciduria
• Methylation
• Mitochondrion
• Phosphoprotein
• Transport

InteractionsUniProt · HPA

Protein binding partners of ETFB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ACADM
• MBTPS1
• ETFRF1
• ETFA