Seroatlas · Human Serome Atlas

PCYT1B

Choline-phosphate cytidylyltransferase B

Also known as: CCT-beta, CCTbeta, CTB, PCY1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5K3
Gene: PCYT1B
Ensembl: ENSG00000102230
Chromosome: X
Canonical length: 369 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q9Y5K3|PCYT1B
     1  MPVVTTDAES ETGIPKSLSN EPPSETMEEI EHTCPQPRLT LTAPAPFADE TNCQCQAPHE
    61  KLTIAQARLG TPADRPVRVY ADGIFDLFHS GHARALMQAK TLFPNSYLLV GVCSDDLTHK
   121  FKGFTVMNEA ERYEALRHCR YVDEVIRDAP WTLTPEFLEK HKIDFVAHDD IPYSSAGSDD
   181  VYKHIKEAGM FVPTQRTEGI STSDIITRIV RDYDVYARRN LQRGYTAKEL NVSFINEKRY
   241  RFQNQVDKMK EKVKNVEERS KEFVNRVEEK SHDLIQKWEE KSREFIGNFL ELFGPDGAWK
   301  QMFQERSSRM LQALSPKQSP VSSPTRSRSP SRSPSPTFSW LPLKTSPPSS PKAASASISS
   361  MSEGDEDEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCYT1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
retina: 11 nTPM
cerebral cortex: 11 nTPM
spinal cord: 10 nTPM
amygdala: 10 nTPM
basal ganglia: 9.7 nTPM

Single-cell type

late spermatids: 156 nCPM
platelets: 147 nCPM
choroid plexus epithelial cells: 108 nCPM
müller glia: 75 nCPM
retinal pigment epithelial cells: 64 nCPM
ependymal cells: 64 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.3 nTPM
total PBMC: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 26 nTPM
white matter: 25 nTPM
basal ganglia: 24 nTPM
amygdala: 24 nTPM
hippocampal formation: 23 nTPM
thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.9
gnomAD missense Z: 2.16
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCYT1B as an antibody target. Whether an autoantibody or antibody against PCYT1B could matter depends on whether native PCYT1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCYT1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCYT1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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