GMPS

Protein identityUniProt · HPA

UniProt accession

P49915

Gene

GMPS

Ensembl

ENSG00000163655

Chromosome

3

Canonical length

693 aa

Protein class

Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>P49915|GMPS
     1  MALCNGDSKL ENAGGDLKDG HHHYEGAVVI LDAGAQYGKV IDRRVRELFV QSEIFPLETP
    61  AFAIKEQGFR AIIISGGPNS VYAEDAPWFD PAIFTIGKPV LGICYGMQMM NKVFGGTVHK
   121  KSVREDGVFN ISVDNTCSLF RGLQKEEVVL LTHGDSVDKV ADGFKVVARS GNIVAGIANE
   181  SKKLYGAQFH PEVGLTENGK VILKNFLYDI AGCSGTFTVQ NRELECIREI KERVGTSKVL
   241  VLLSGGVDST VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA
   301  HSFYNGTTTL PISDEDRTPR KRISKTLNMT TSPEEKRKII GDTFVKIANE VIGEMNLKPE
   361  EVFLAQGTLR PDLIESASLV ASGKAELIKT HHNDTELIRK LREEGKVIEP LKDFHKDEVR
   421  ILGRELGLPE ELVSRHPFPG PGLAIRVICA EEPYICKDFP ETNNILKIVA DFSASVKKPH
   481  TLLQRVKACT TEEDQEKLMQ ITSLHSLNAF LLPIKTVGVQ GDCRSYSYVC GISSKDEPDW
   541  ESLIFLARLI PRMCHNVNRV VYIFGPPVKE PPTDVTPTFL TTGVLSTLRQ ADFEAHNILR
   601  ESGYAGKISQ MPVILTPLHF DRDPLQKQPS CQRSVVIRTF ITSDFMTGIP ATPGNEIPVE
   661  VVLKMVTEIK KIPGISRIMY DLTSKPPGTT EWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

94 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.24

gnomAD pLI

1

gnomAD missense Z

2.37

DepMap mean gene effect

-1.02

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• GMP biosynthetic process
• purine nucleobase biosynthetic process
• purine ribonucleoside monophosphate biosynthetic process

Molecular functions

• ATP binding
• GMP synthase (glutamine-hydrolyzing) activity
• GMP synthase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Rossmann-like alpha/beta/alpha sandwich fold
• Glutamine amidotransferase
• NAD/GMP synthase
• Class I glutamine amidotransferase-like
• Glutamine amidotransferase class-I
• NAD synthase
• GMP synthase, C-terminal
• GMP synthase, glutamine amidotransferase
• GMP synthetase ATP pyrophosphatase domain
• GMP synthase C terminal domain

KeywordsUniProt

• Acetylation
• ATP-binding
• Chromosomal rearrangement
• Cytoplasm
• Glutamine amidotransferase
• GMP biosynthesis
• Ligase
• Nucleotide-binding
• Phosphoprotein
• Proto-oncogene
• Purine biosynthesis