YARS1

Protein identityUniProt · HPA

UniProt accession

P54577

Gene

YARS1

Ensembl

ENSG00000134684

Chromosome

1

Canonical length

528 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nuclear bodies,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>P54577|YARS1
     1  MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA
    61  DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG
   121  TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD
   181  AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED
   241  VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA
   301  AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP
   361  EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV
   421  VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE
   481  LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YARS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

80 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YARS1.

Disease | AllUniProt

Conditions YARS1 is implicated in, by any mechanism.

• Charcot-Marie-Tooth disease, dominant intermediate C (CMTDIC) MIM:608323
• Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2 (IMNEPD2) MIM:619418

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 656 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Charcot-Marie-Tooth disease dominant intermediate C
• Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2
• Charcot-Marie-Tooth disease
• Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset
• Hepatic steatosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.62

gnomAD pLI

0

DepMap mean gene effect

-1.95

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• response to starvation
• tyrosyl-tRNA aminoacylation

Molecular functions

• ATP binding
• interleukin-8 receptor binding
• RNA binding
• small molecule binding
• tRNA binding
• tyrosine-tRNA ligase activity

Cellular components

• cytoplasm
• cytosol
• extracellular space
• nuclear body
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Aminoacyl-tRNA synthetase, class Ic
• Tyrosine-tRNA ligase
• tRNA-binding domain
• Nucleic acid-binding, OB-fold
• Rossmann-like alpha/beta/alpha sandwich fold
• tRNA synthetases class I (W and Y)
• Putative tRNA binding domain

KeywordsUniProt

• Acetylation
• Aminoacyl-tRNA synthetase
• ATP-binding
• Charcot-Marie-Tooth disease
• Cytoplasm
• Ligase
• Neurodegeneration
• Neuropathy
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Protein biosynthesis
• RNA-binding
• tRNA-binding

InteractionsUniProt · HPA

Protein binding partners of YARS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PARP1