Seroatlas · Human Serome Atlas

RARS1

Arginine--tRNA ligase, cytoplasmic

Also known as: DALRD1, RARS, SYRC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54136
Gene
RARS1
Ensembl
ENSG00000113643
Chromosome
5
Canonical length
660 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

660 residues, UniProt reviewed canonical sequence.

>P54136|RARS1
     1  MDVLVSECSA RLLQQEEEIK SLTAEIDRLK NCGCLGASPN LEQLQEENLK LKYRLNILRK
    61  SLQAERNKPT KNMINIISRL QEVFGHAIKA AYPDLENPPL LVTPSQQAKF GDYQCNSAMG
   121  ISQMLKTKEQ KVNPREIAEN ITKHLPDNEC IEKVEIAGPG FINVHLRKDF VSEQLTSLLV
   181  NGVQLPALGE NKKVIVDFSS PNIAKEMHVG HLRSTIIGES ISRLFEFAGY DVLRLNHVGD
   241  WGTQFGMLIA HLQDKFPDYL TVSPPIGDLQ VFYKESKKRF DTEEEFKKRA YQCVVLLQGK
   301  NPDITKAWKL ICDVSRQELN KIYDALDVSL IERGESFYQD RMNDIVKEFE DRGFVQVDDG
   361  RKIVFVPGCS IPLTIVKSDG GYTYDTSDLA AIKQRLFEEK ADMIIYVVDN GQSVHFQTIF
   421  AAAQMIGWYD PKVTRVFHAG FGVVLGEDKK KFKTRSGETV RLMDLLGEGL KRSMDKLKEK
   481  ERDKVLTAEE LNAAQTSVAY GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR
   541  IRSIARLANI DEEMLQKAAR ETKILLDHEK EWKLGRCILR FPEILQKILD DLFLHTLCDY
   601  IYELATAFTE FYDSCYCVEK DRQTGKILKV NMWRMLLCEA VAAVMAKGFD ILGIKPVQRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RARS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 52 nTPM
  • small intestine: 46 nTPM
  • liver: 41 nTPM
  • rectum: 40 nTPM
  • skin: 40 nTPM
  • urinary bladder: 38 nTPM

Single-cell type

  • esophageal suprabasal cells: 173 nCPM
  • enterocytes: 169 nCPM
  • endometrial glandular cells: 165 nCPM
  • migrating cytotrophoblasts: 163 nCPM
  • cytotrophoblasts: 159 nCPM
  • extravillous trophoblasts: 158 nCPM

Immune cell

  • myeloid DC: 32 nTPM
  • intermediate monocyte: 27 nTPM
  • non-classical monocyte: 27 nTPM
  • NK-cell: 27 nTPM
  • naive CD8 T-cell: 23 nTPM
  • classical monocyte: 22 nTPM

Brain region

  • white matter: 64 nTPM
  • cerebellum: 62 nTPM
  • cerebral cortex: 52 nTPM
  • amygdala: 46 nTPM
  • hippocampal formation: 45 nTPM
  • hypothalamus: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RARS1.

Disease | AllUniProt

Conditions RARS1 is implicated in, by any mechanism.

  • Leukodystrophy, hypomyelinating, 9 (HLD9) MIM:616140

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 464 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
DepMap mean gene effect
-0.79
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RARS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RARS1 as an antibody target. Whether an autoantibody or antibody against RARS1 could matter depends on whether native RARS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RARS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RARS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RARS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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