Seroatlas · Human Serome Atlas

NMNAT3

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Also known as: NMNA3_HUMAN, PNAT3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96T66
Gene: NMNAT3
Ensembl: ENSG00000163864
Chromosome: 3
Canonical length: 252 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>Q96T66|NMNAT3
     1  MKSRIPVVLL ACGSFNPITN MHLRMFEVAR DHLHQTGMYQ VIQGIISPVN DTYGKKDLAA
    61  SHHRVAMARL ALQTSDWIRV DPWESEQAQW METVKVLRHH HSKLLRSPPQ MEGPDHGKAL
   121  FSTPAAVPEL KLLCGADVLK TFQTPNLWKD AHIQEIVEKF GLVCVGRVGH DPKGYIAESP
   181  ILRMHQHNIH LAKEPVQNEI SATYIRRALG QGQSVKYLIP DAVITYIKDH GLYTKGSTWK
   241  GKSTQSTEGK TS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMNAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

retina: 24 nTPM
skeletal muscle: 24 nTPM
skin: 18 nTPM
tongue: 17 nTPM
ovary: 16 nTPM
bone marrow: 16 nTPM

Single-cell type

late spermatids: 333 nCPM
erythrocyte progenitors: 180 nCPM
rod photoreceptor cells: 179 nCPM
late primary spermatocytes: 172 nCPM
megakaryocyte progenitors: 170 nCPM
myonuclei: 153 nCPM

Immune cell

basophil: 8 nTPM
neutrophil: 4.4 nTPM
naive B-cell: 3 nTPM
naive CD8 T-cell: 2.8 nTPM
intermediate monocyte: 2.7 nTPM
naive CD4 T-cell: 2.7 nTPM

Brain region

white matter: 193 nTPM
cerebellum: 190 nTPM
cerebral cortex: 190 nTPM
hippocampal formation: 157 nTPM
basal ganglia: 156 nTPM
amygdala: 153 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.16
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMNAT3 as an antibody target. Whether an autoantibody or antibody against NMNAT3 could matter depends on whether native NMNAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMNAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NMNAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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