Keratin, type II
IPR003054
Definition
Intermediate filaments (IF) [[cite:PMID:8771189], [cite:PMID:3052284], [cite:PMID:2183847]] are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide. Type II keratins are the basic or neutral courterparts to the acidic type I keratins. Each type II keratin forms a heterodimer with a specific acidic keratin, and the heterodimers are organised into tetramers and then into chains PMID:2183847. Type II keratins consist of head-, rod- and tail-like structures, the rod being constructed from three linked coils: 1A, 1B and 2. The head and tail structures of the type 2 keratins are highly variable low-complexity regions. This protein family also includes Intermediate filament protein ON3 from Carassius auratus (Goldfish), one of the non-neuronal predominant intermediate filament proteins of the visual pathway PMID:2483326.
27 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...