Seroatlas · Human Serome Atlas

KRT77

Keratin, type II cytoskeletal 1b

Also known as: K2C1B_HUMAN, KRT1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z794
Gene
KRT77
Ensembl
ENSG00000189182
Chromosome
12
Canonical length
578 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear membrane,Plasma membrane

OverviewNCBI Gene

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q7Z794|KRT77
     1  MSHQFSSQSA FSSMSRRVYS TSSSAGSGGG SPAVGSVCYA RGRCGGGGYG IHGRGFGSRS
    61  LYNLGGSRSI SINLMGRSTS GFCQGGGVGG FGGGRGFGVG STGAGGFGGG GFGGAGFGTS
   121  NFGLGGFGPY CPPGGIQEVT INQSLLEPLH LEVDPEIQRI KTQEREQIMV LNNKFASFID
   181  KVRFLEQQNQ VLQTKWELLQ QVNTSTGTNN LEPLLENYIG DLRRQVDLLS AEQMRQNAEV
   241  RSMQDVVEDY KSKYEDEINK RTGSENDFVV LKKDVDAAYV SKVDLESRVD TLTGEVNFLK
   301  YLFLTELSQV QTHISDTNVI LSMDNNRSLD LDSIIDAVRT QYELIAQRSK DEAEALYQTK
   361  YQELQITAGR HGDDLKNSKM EIAELNRTVQ RLQAEISNVK KQIEQMQSLI SDAEERGEQA
   421  LQDAWQKLQD LEEALQQSKE ELARLLRDYQ AMLGVKLSLD VEIATYRQLL EGEESRMSGE
   481  LQSHVSISVQ NSQVSVNGGA GGGGSYGSGG YGGGSGGGYG GGRSYRGGGA RGRSGGGYGS
   541  GCGGGGGSYG GSGRSGRGSS RVQIIQTSTN TSHRRILE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT77 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
262 nTPM

Expression across tissuesHPA

Tissue

  • skin: 262 nTPM
  • breast: 18 nTPM
  • thymus: 0.8 nTPM
  • skeletal muscle: 0.7 nTPM
  • salivary gland: 0.6 nTPM
  • adipose tissue: 0.5 nTPM

Single-cell type

  • suprabasal keratinocytes: 17 nCPM
  • basal keratinocytes: 1.6 nCPM
  • submucosal glandular cells: 0.9 nCPM
  • undifferentiated spermatogonia: 0.4 nCPM
  • late primary spermatocytes: 0.3 nCPM
  • other brain neurons: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0
gnomAD missense Z
-0.46
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT77 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT77 as an antibody target. Whether an autoantibody or antibody against KRT77 could matter depends on whether native KRT77 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT77 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT77 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRT77. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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