Seroatlas · Human Serome Atlas

KRT86

Keratin, type II cuticular Hb6

Also known as: Hb6, KRT86_HUMAN, KRTHB6, MNX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43790
Gene: KRT86
Ensembl: ENSG00000170442
Chromosome: 12
Canonical length: 486 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>O43790|KRT86
     1  MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG
    61  RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF
   121  IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL
   181  NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR
   241  RLYEEEIRVL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK
   301  CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA
   361  LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG
   421  VGSVNVCVSS SRGGVVCGDL CASTTAPVVS TRVSSVPSNS NVVVGTTNAC APSARVGVCG
   481  GSCKRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT86 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 136 nTPM

Expression across tissuesHPA

Tissue

skin: 136 nTPM
testis: 3.9 nTPM
thyroid gland: 3.8 nTPM
salivary gland: 3.6 nTPM
blood vessel: 3.3 nTPM
bone marrow: 2.5 nTPM

Single-cell type

salivary basal cells: 131 nCPM
salivary acinar cells: 124 nCPM
epididymal basal cells: 114 nCPM
epididymal clear cells: 88 nCPM
salivary myoepithelial cells: 78 nCPM
endometrial luminal cells: 73 nCPM

Immune cell

basophil: 88 nTPM
NK-cell: 9.7 nTPM
total PBMC: 0.5 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 5 nTPM
cerebral cortex: 4.2 nTPM
basal ganglia: 4 nTPM
hypothalamus: 3.5 nTPM
midbrain: 3.5 nTPM
pons: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KRT86.

Disease | AllUniProt

Conditions KRT86 is implicated in, by any mechanism.

Monilethrix 1 (MNLIX1) MIM:158000

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 161 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Monilethrix
Monilethrix-1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -1.27
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT86 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT86 as an antibody target. Whether an autoantibody or antibody against KRT86 could matter depends on whether native KRT86 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT86 is annotated as secreted, so native KRT86 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KRT86 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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