Seroatlas · Human Serome Atlas

KRT71

Keratin, type II cytoskeletal 71

Also known as: K2C71_HUMAN, K6IRS1, KRT6IRS, KRT6IRS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3SY84
Gene: KRT71
Ensembl: ENSG00000139648
Chromosome: 12
Canonical length: 523 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q3SY84|KRT71
     1  MSRQFTCKSG AAAKGGFSGC SAVLSGGSSS SFRAGSKGLS GGFGSRSLYS LGGVRSLNVA
    61  SGSGKSGGYG FGRGRASGFA GSMFGSVALG PVCPTVCPPG GIHQVTVNES LLAPLNVELD
   121  PEIQKVRAQE REQIKALNNK FASFIDKVRF LEQQNQVLET KWELLQQLDL NNCKNNLEPI
   181  LEGYISNLRK QLETLSGDRV RLDSELRNVR DVVEDYKKRY EEEINKRTAA ENEFVLLKKD
   241  VDAAYANKVE LQAKVESMDQ EIKFFRCLFE AEITQIQSHI SDMSVILSMD NNRNLDLDSI
   301  IDEVRTQYEE IALKSKAEAE ALYQTKFQEL QLAAGRHGDD LKNTKNEISE LTRLIQRIRS
   361  EIENVKKQAS NLETAIADAE QRGDNALKDA RAKLDELEGA LHQAKEELAR MLREYQELMS
   421  LKLALDMEIA TYRKLLESEE CRMSGEFPSP VSISIISSTS GGSVYGFRPS MVSGGYVANS
   481  SNCISGVCSV RGGEGRSRGS ANDYKDTLGK GSSLSAPSKK TSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT71 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

skin: 91 nTPM
epididymis: 4.1 nTPM
adipose tissue: 2 nTPM
salivary gland: 1.6 nTPM
breast: 1 nTPM
thymus: 0.6 nTPM

Single-cell type

epididymal principal cells: 7.9 nCPM
pericytes: 0.4 nCPM
cdc: 0.3 nCPM
early spermatids: 0.1 nCPM
enterocytes: 0.1 nCPM
epididymal efferent duct absorptive cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.6 nTPM
midbrain: 0.3 nTPM
white matter: 0.2 nTPM
spinal cord: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KRT71.

Disease | AllUniProt

Conditions KRT71 is implicated in, by any mechanism.

Hypotrichosis 13 (HYPT13) MIM:615896

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 205 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypotrichosis 13

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT71 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT71 as an antibody target. Whether an autoantibody or antibody against KRT71 could matter depends on whether native KRT71 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT71 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT71 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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