Seroatlas · Human Serome Atlas

KRT81

Keratin, type II cuticular Hb1

Also known as: Hb-1, KRT81_HUMAN, KRTHB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14533
Gene: KRT81
Ensembl: ENSG00000205426
Chromosome: 12
Canonical length: 505 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. Some human genome assemblies (example T2T-CHM13) have a non-coding version of the gene due to the presence of a SNP that introduces a premature stop codon after codon 281. [provided by RefSeq, Jan 2024]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q14533|KRT81
     1  MTCGSGFGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG
    61  RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF
   121  IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL
   181  NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR
   241  RLYEEEILIL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK
   301  CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA
   361  LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG
   421  IGAVNVCVSS SRGGVVCGDL CVSGSRPVTG SVCSAPCNGN VAVSTGLCAP CGQLNTTCGG
   481  GSCGVGSCGI SSLGVGSCGS SCRKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT81 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

skin: 131 nTPM
salivary gland: 3.9 nTPM
breast: 2.9 nTPM
adipose tissue: 1.2 nTPM
placenta: 1 nTPM
spinal cord: 1 nTPM

Single-cell type

breast myoepithelial cells: 223 nCPM
breast secretory cells: 197 nCPM
nk-cells: 60 nCPM
innate lymphoid cells: 54 nCPM
conjunctival goblet cells: 39 nCPM
submucosal glandular cells: 27 nCPM

Immune cell

basophil: 172 nTPM
NK-cell: 3.5 nTPM
total PBMC: 0.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 1.2 nTPM
hypothalamus: 0.9 nTPM
basal ganglia: 0.7 nTPM
medulla oblongata: 0.7 nTPM
pons: 0.7 nTPM
thalamus: 0.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KRT81.

Disease | AllUniProt

Conditions KRT81 is implicated in, by any mechanism.

Monilethrix 2 (MNLIX2) MIM:621169

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 139 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Monilethrix-2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT81 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT81 as an antibody target. Whether an autoantibody or antibody against KRT81 could matter depends on whether native KRT81 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT81 is annotated as secreted, so native KRT81 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KRT81 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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