Seroatlas · Human Serome Atlas

KRT83

Keratin, type II cuticular Hb3

Also known as: Hb-3, KRT83_HUMAN, KRTHB3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78385
Gene
KRT83
Ensembl
ENSG00000170523
Chromosome
12
Canonical length
493 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>P78385|KRT83
     1  MTCGFNSIGC GFRPGNFSCV SACGPRPSRC CITAAPYRGI SCYRGLTGGF GSHSVCGGFR
    61  AGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI DPNAQCVKQE EKEQIKSLNS
   121  RFAAFIDKVR FLEQQNKLLE TKLQFYQNRE CCQSNLEPLF AGYIETLRRE AECVEADSGR
   181  LASELNHVQE VLEGYKKKYE EEVALRATAE NEFVALKKDV DCAYLRKSDL EANVEALIQE
   241  IDFLRRLYEE EIRILQSHIS DTSVVVKLDN SRDLNMDCIV AEIKAQYDDI ATRSRAEAES
   301  WYRSKCEEMK ATVIRHGETL RRTKEEINEL NRMIQRLTAE VENAKCQNSK LEAAVAQSEQ
   361  QGEAALSDAR CKLAELEGAL QKAKQDMACL IREYQEVMNS KLGLDIEIAT YRRLLEGEEQ
   421  RLCEGVEAVN VCVSSSRGGV VCGDLCVSGS RPVTGSVCSA PCNGNLVVST GLCKPCGQLN
   481  TTCGGGSCGQ GRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT83 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • skin: 61 nTPM
  • spinal cord: 2 nTPM
  • salivary gland: 1.9 nTPM
  • thyroid gland: 0.9 nTPM
  • adipose tissue: 0.8 nTPM
  • midbrain: 0.8 nTPM

Single-cell type

  • innate lymphoid cells: 2 nCPM
  • breast secretory cells: 1.2 nCPM
  • neuroendocrine cells: 0.9 nCPM
  • salivary acinar cells: 0.8 nCPM
  • urothelial cells: 0.8 nCPM
  • salivary myoepithelial cells: 0.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 3.1 nTPM
  • basal ganglia: 1 nTPM
  • spinal cord: 1 nTPM
  • pons: 0.9 nTPM
  • cerebellum: 0.8 nTPM
  • cerebral cortex: 0.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KRT83.

Disease | AllUniProt

Conditions KRT83 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 252 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Monilethrix-3
  • Monilethrix
  • Erythrokeratodermia variabilis et progressiva 5

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
-1.24
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT83 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT83 as an antibody target. Whether an autoantibody or antibody against KRT83 could matter depends on whether native KRT83 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT83 is annotated as secreted, so native KRT83 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KRT83 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRT83. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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