Seroatlas · Human Serome Atlas

KRT79

Keratin, type II cytoskeletal 79

Also known as: K2C79_HUMAN, K6L, KRT6L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5XKE5
Gene: KRT79
Ensembl: ENSG00000185640
Chromosome: 12
Canonical length: 535 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>Q5XKE5|KRT79
     1  MRSSVSRQTY STKGGFSSNS ASGGSGSQAR TSFSSVTVSR SSGSGGGAHC GPGTGGFGSR
    61  SLYNLGGHKS ISVSVAGGAL LGRALGGFGF GSRAFMGQGA GRQTFGPACP PGGIQEVTVN
   121  QSLLTPLHVE IDPEIQRVRT QEREQIKTLN NKFASFIDKV RFLEQQNKVL ETKWALLQEQ
   181  GQNLGVTRNN LEPLFEAYLG SMRSTLDRLQ SERGRLDSEL RNVQDLVEDF KNKYEDEINK
   241  HTAAENEFVV LKKDVDAAYM GRMDLHGKVG TLTQEIDFLQ QLYEMELSQV QTHVSNTNVV
   301  LSMDNNRNLD LDSIIAEVKA QYELIAQRSR AEAEAWYQTK YEELQVTAGK HGDNLRDTKN
   361  EIAELTRTIQ RLQGEADAAK KQCQQLQTAI AEAEQRGELA LKDAQKKLGD LDVALHQAKE
   421  DLTRLLRDYQ ELMNVKLALD VEIATYRKLL ESEESRMSGE CPSAVSISVT GNSTTVCGGG
   481  AASFGGGISL GGSGGATKGG FSTNVGYSTV KGGPVSAGTS ILRKTTTVKT SSQRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT79 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

skin: 67 nTPM
breast: 3.1 nTPM
thymus: 1.8 nTPM
esophagus: 1.3 nTPM
lung: 0.5 nTPM
vagina: 0.4 nTPM

Single-cell type

late spermatids: 3.9 nCPM
esophageal apical cells: 3.6 nCPM
early spermatids: 0.9 nCPM
mast cells: 0.8 nCPM
endometrial glandular cells: 0.6 nCPM
endometrial luminal cells: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT79 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT79 as an antibody target. Whether an autoantibody or antibody against KRT79 could matter depends on whether native KRT79 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT79 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT79 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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