KRT73
Keratin, type II cytoskeletal 73
Also known as: K2C73_HUMAN, K6IRS3, KRT6IRS3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86Y46
- Gene
- KRT73
- Ensembl
- ENSG00000186049
- Chromosome
- 12
- Canonical length
- 540 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
OverviewNCBI Gene
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Canonical amino-acid sequenceUniProt
540 residues, UniProt reviewed canonical sequence.
>Q86Y46|KRT73
1 MSRQFTYKSG AAAKGGFSGC SAVLSGGSSS SYRAGGKGLS GGFSSRSLYS LGGARSISFN
61 VASGSGWAGG YGFGRGRASG FAGSMFGSVA LGSVCPSLCP PGGIHQVTIN KSLLAPLNVE
121 LDPEIQKVRA QEREQIKVLN NKFASFIDKV RFLEQQNQVL ETKWELLQQL DLNNCKNNLE
181 PILEGYISNL RKQLETLSGD RVRLDSELRS VREVVEDYKK RYEEEINKRT TAENEFVVLK
241 KDVDAAYTSK VELQAKVDAL DGEIKFFKCL YEGETAQIQS HISDTSIILS MDNNRNLDLD
301 SIIAEVRAQY EEIARKSKAE AEALYQTKFQ ELQLAAGRHG DDLKHTKNEI SELTRLIQRL
361 RSEIESVKKQ CANLETAIAD AEQRGDCALK DARAKLDELE GALQQAKEEL ARMLREYQEL
421 LSVKLSLDIE IATYRKLLEG EECRMSGEYT NSVSISVINS SMAGMAGTGA GFGFSNAGTY
481 GYWPSSVSGG YSMLPGGCVT GSGNCSPRGE ARTRLGSASE FRDSQGKTLA LSSPTKKTMRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KRT73 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- skin: 17 nTPM
- lymph node: 1.9 nTPM
- bone marrow: 1.2 nTPM
- small intestine: 0.8 nTPM
- appendix: 0.7 nTPM
- duodenum: 0.7 nTPM
Single-cell type
- nk-cells: 2 nCPM
- early spermatids: 1.4 nCPM
- late spermatids: 1.2 nCPM
- thymocytes: 0.8 nCPM
- retinal amacrine cells: 0.7 nCPM
- t-cells: 0.7 nCPM
Immune cell
- naive CD4 T-cell: 8.9 nTPM
- naive CD8 T-cell: 3.1 nTPM
- total PBMC: 1.2 nTPM
- memory CD4 T-cell: 0.8 nTPM
- NK-cell: 0.6 nTPM
- memory CD8 T-cell: 0.2 nTPM
Brain region
- spinal cord: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.26
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.44
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KRT73 as an antibody target. Whether an autoantibody or antibody against KRT73 could matter depends on whether native KRT73 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KRT73 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KRT73 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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