Seroatlas · Human Serome Atlas

KRT74

Keratin, type II cytoskeletal 74

Also known as: K2C74_HUMAN, K6IRS4, KRT5C, KRT6IRS4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTS7
Gene: KRT74
Ensembl: ENSG00000170484
Chromosome: 12
Canonical length: 529 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoli,Intermediate filaments,Cytosol

OverviewNCBI Gene

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q7RTS7|KRT74
     1  MSRQLNIKSS GDKGNFSVHS AVVPRKAVGS LASYCAAGRG AGAGFGSRSL YSLGGNRRIS
    61  FNVAGGGVRA GGYGFRPGSG YGGGRASGFA GSMFGSVALG PACLSVCPPG GIHQVTVNKS
   121  LLAPLNVELD PEIQKVRAQE REQIKVLNDK FASFIDKVRF LEQQNQVLET KWELLQQLDL
   181  NNCKKNLEPI LEGYISNLRK QLETLSGDRV RLDSELRSMR DLVEDYKKRY EVEINRRTTA
   241  ENEFVVLKKD ADAAYAVKVE LQAKVDSLDK EIKFLKCLYD AEIAQIQTHA SETSVILSMD
   301  NNRDLDLDSI IAEVRMHYEE IALKSKAEAE ALYQTKIQEL QLAASRHGDD LKHTRSEMVE
   361  LNRLIQRIRC EIGNVKKQRA SLETAIADAE QRGDNALKDA QAKLDELEGA LHQAKEELAR
   421  MLREYQELMS LKLALDMEIA TYRKLLEGEE CRMSGENPSS VSISVISSSS YSYHHPSSAG
   481  VDLGASAVAG SSGSTQSGQT KTTEARGGDL KDTQGKSTPA SIPARKATR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT74 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skin: 15 nTPM
epididymis: 5.3 nTPM
breast: 0.7 nTPM
testis: 0.6 nTPM
spinal cord: 0.4 nTPM
adipose tissue: 0.2 nTPM

Single-cell type

late spermatids: 7.7 nCPM
epididymal principal cells: 2.5 nCPM
early spermatids: 0.5 nCPM
epididymal basal cells: 0.5 nCPM
ocular epithelial cells: 0.5 nCPM
schwann cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.3 nTPM
medulla oblongata: 0.1 nTPM
spinal cord: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KRT74.

Disease | AllUniProt

Conditions KRT74 is implicated in, by any mechanism.

Woolly hair autosomal dominant (ADWH) MIM:194300
Hypotrichosis 3 (HYPT3) MIM:613981
Ectodermal dysplasia 7, hair/nail type (ECTD7) MIM:614929

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 240 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autosomal dominant wooly hair
Hypotrichosis 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -1.2
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT74 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KRT19

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT74 as an antibody target. Whether an autoantibody or antibody against KRT74 could matter depends on whether native KRT74 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT74 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT74 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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