Seroatlas · Human Serome Atlas

KRT7

Keratin, type II cytoskeletal 7

Also known as: CK-7, CK7, K2C7, K2C7_HUMAN, K7, SCL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P08729
Gene: KRT7
Ensembl: ENSG00000135480
Chromosome: 12
Canonical length: 469 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>P08729|KRT7
     1  MSIHFSSPVF TSRSAAFSGR GAQVRLSSAR PGGLGSSSLY GLGASRPRVA VRSAYGGPVG
    61  AGIREVTINQ SLLAPLRLDA DPSLQRVRQE ESEQIKTLNN KFASFIDKVR FLEQQNKLLE
   121  TKWTLLQEQK SAKSSRLPDI FEAQIAGLRG QLEALQVDGG RLEAELRSMQ DVVEDFKNKY
   181  EDEINHRTAA ENEFVVLKKD VDAAYMSKVE LEAKVDALND EINFLRTLNE TELTELQSQI
   241  SDTSVVLSMD NSRSLDLDGI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD
   301  LRNTRNEISE MNRAIQRLQA EIDNIKNQRA KLEAAIAEAE ERGELALKDA RAKQEELEAA
   361  LQRGKQDMAR QLREYQELMS VKLALDIEIA TYRKLLEGEE SRLAGDGVGA VNISVMNSTG
   421  GSSSGGGIGL TLGGTMGSNA LSFSSSAGPG LLKAYSIRTA SASRRSARD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 952 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 952 nTPM
thyroid gland: 406 nTPM
lung: 342 nTPM
urinary bladder: 242 nTPM
placenta: 200 nTPM
breast: 157 nTPM

Single-cell type

alveolar cells type 1: 7,674 nCPM
extravillous trophoblasts: 5,987 nCPM
migrating cytotrophoblasts: 2,714 nCPM
salivary ionocytes: 2,130 nCPM
cytotrophoblasts: 1,975 nCPM
salivary duct cells: 1,683 nCPM

Immune cell

intermediate monocyte: 0.9 nTPM
myeloid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 0.9 nTPM
medulla oblongata: 0.3 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
spinal cord: 0.2 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT7 as an antibody target. Whether an autoantibody or antibody against KRT7 could matter depends on whether native KRT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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