Seroatlas · Human Serome Atlas

KRT78

Keratin, type II cytoskeletal 78

Also known as: K2C78_HUMAN, K5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1N4
Gene: KRT78
Ensembl: ENSG00000170423
Chromosome: 12
Canonical length: 520 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q8N1N4|KRT78
     1  MSLSPCRAQR GFSARSACSA RSRGRSRGGF SSRGGFSSRS LNSFGGCLEG SRGSTWGSGG
    61  RLGVRFGEWS GGPGLSLCPP GGIQEVTINQ NLLTPLKIEI DPQFQVVRTQ ETQEIRTLNN
   121  QFASFIDKVR FLEQQNKVLE TKWHLLQQQG LSGSQQGLEP VFEACLDQLR KQLEQLQGER
   181  GALDAELKAC RDQEEEYKSK YEEEAHRRAT LENDFVVLKK DVDGVFLSKM ELEGKLEALR
   241  EYLYFLKHLN EEELGQLQTQ ASDTSVVLSM DNNRYLDFSS IITEVRARYE EIARSSKAEA
   301  EALYQTKYQE LQVSAQLHGD RMQETKVQIS QLHQEIQRLQ SQTENLKKQN ASLQAAITDA
   361  EQRGELALKD AQAKVDELEA ALRMAKQNLA RLLCEYQELT STKLSLDVEI ATYRRLLEGE
   421  ECRMSGECTS QVTISSVGGS AVMSGGVGGG LGSTCGLGSG KGSPGSCCTS IVTGGSNIIL
   481  GSGKDPVLDS CSVSGSSAGS SCHTILKKTV ESSLKTSITY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT78 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 880 nTPM

Expression across tissuesHPA

Tissue

esophagus: 880 nTPM
vagina: 187 nTPM
cervix: 138 nTPM
tonsil: 126 nTPM
skin: 112 nTPM
salivary gland: 105 nTPM

Single-cell type

esophageal apical cells: 7,863 nCPM
suprabasal keratinocytes: 256 nCPM
esophageal suprabasal cells: 45 nCPM
esophageal basal cells: 14 nCPM
ocular epithelial cells: 9.5 nCPM
submucosal glandular cells: 8.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.7 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -0.48
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of skin epidermis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT78 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KRT14

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT78 as an antibody target. Whether an autoantibody or antibody against KRT78 could matter depends on whether native KRT78 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT78 is annotated as secreted, so native KRT78 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KRT78 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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