Laminin G domain
IPR001791
Definition
Laminins are large heterotrimeric glycoproteins involved in basement membrane function PMID:15037599. The Laminin G or LNS domain (for Laminin-alpha, Neurexin and Sex hormone-binding globulin) is an around 180 amino acid long domain found in a large and diverse set of extracellular proteins [[cite:PMID:1975589], [cite:PMID:9480764]]. The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. The C terminus of the laminin alpha chain contains a tandem repeat of five laminin G domains, which are critical for heparin-binding and cell attachment activity PMID:10747011. Laminin alpha4 is distributed in a variety of tissues including peripheral nerves, dorsal root ganglion, skeletal muscle and capillaries; in the neuromuscular junction, it is required for synaptic specialisation PMID:15823034. The structure of the laminin-G domain has been predicted to resemble that of pentraxin PMID:9480764. Laminin G domains can vary in their function, and a variety of binding functions have been ascribed to different LamG modules. For example, the laminin alpha1 and alpha2 chains each have five C-teminal laminin G domains, where only domains LG4 and LG5 contain binding sites for heparin, sulphatides and the cell surface receptor dystroglycan PMID:10747011. Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. Proteins with laminin-G domains include: Laminin. Merosin. Agrin. Neurexins. Vitamin K dependent protein S. Sex steroid binding protein SBP/SHBG. Drosophila proteins Slit, Crumbs, Fat. several proteoglycan precursors.
40 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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