Seroatlas · Human Serome Atlas

BMP5

Bone morphogenetic protein 5

Also known as: BMP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P22003
Gene
BMP5
Ensembl
ENSG00000112175
Chromosome
6
Canonical length
454 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>P22003|BMP5
     1  MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG
    61  LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP
   121  NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF
   181  RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA
   241  QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF
   301  MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV
   361  SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA
   421  PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 67 nTPM
  • prostate: 13 nTPM
  • lung: 12 nTPM
  • tongue: 11 nTPM
  • small intestine: 9.2 nTPM
  • urinary bladder: 8.7 nTPM

Single-cell type

  • fibro-adipogenic progenitors: 283 nCPM
  • pericytes: 88 nCPM
  • pancreatic islet cells: 70 nCPM
  • fibroblasts: 63 nCPM
  • vascular smooth muscle cells: 57 nCPM
  • adipocytes: 54 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 6.6 nTPM
  • choroid plexus: 4.6 nTPM
  • medulla oblongata: 2.7 nTPM
  • cerebellum: 1.5 nTPM
  • cerebral cortex: 1.2 nTPM
  • basal ganglia: 1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BMP5.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 98 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microtia
  • Patellar aplasia
  • Hypoplastic ischiopubic ramus
  • Atrioventricular canal defect

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BMP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP5 as an antibody target. Whether an autoantibody or antibody against BMP5 could matter depends on whether native BMP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP5 is annotated as secreted, so native BMP5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BMP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BMP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...