Seroatlas · Human Serome Atlas

BMP8B

Bone morphogenetic protein 8B

Also known as: BMP8, BMP8B_HUMAN, OP-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P34820
Gene: BMP8B
Ensembl: ENSG00000116985
Chromosome: 1
Canonical length: 402 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>P34820|BMP8B
     1  MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA VLGLPGRPRP
    61  RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG RADLVMSFVN MVERDRALGH
   121  QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF
   181  FLDLQTLRAG DEGWLVLDVT AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA
   241  PRSQQPFVVT FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV
   301  CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD
   361  AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

pancreas: 6.5 nTPM
adrenal gland: 5.2 nTPM
duodenum: 5.1 nTPM
thyroid gland: 4.4 nTPM
small intestine: 3.9 nTPM
colon: 3.6 nTPM

Single-cell type

late spermatids: 170 nCPM
early spermatids: 140 nCPM
schwann cells: 37 nCPM
plasma cells: 36 nCPM
adrenal medulla cells: 21 nCPM
oligodendrocyte progenitor cells: 16 nCPM

Immune cell

NK-cell: 0.6 nTPM
memory CD8 T-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

medulla oblongata: 32 nTPM
cerebral cortex: 13 nTPM
white matter: 12 nTPM
midbrain: 10 nTPM
pons: 10 nTPM
hippocampal formation: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP8B as an antibody target. Whether an autoantibody or antibody against BMP8B could matter depends on whether native BMP8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP8B is annotated as secreted, so native BMP8B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BMP8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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