Seroatlas · Human Serome Atlas

BMP8A

Bone morphogenetic protein 8A

Also known as: BMP8A_HUMAN, OP-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5Y6
Gene: BMP8A
Ensembl: ENSG00000183682
Chromosome: 1
Canonical length: 402 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q7Z5Y6|BMP8A
     1  MAARPGPLWL LGLTLCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA VLGLPGRPRP
    61  RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAEQRLG RADLVMSFVN MVERDRALGH
   121  QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF
   181  FLDLQTLRAG DEGWLVLDVT AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA
   241  PRSQQPFVVT FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVRGSHGRQV
   301  CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMKPN
   361  AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 86 nTPM
spinal cord: 12 nTPM
ovary: 9.1 nTPM
thymus: 5.4 nTPM
smooth muscle: 4.8 nTPM
cerebral cortex: 4.6 nTPM

Single-cell type

late spermatids: 320 nCPM
epicardial cells: 93 nCPM
early spermatids: 78 nCPM
cardiomyocytes: 27 nCPM
epididymal clear cells: 27 nCPM
thymocytes: 20 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.4 nTPM
memory B-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

white matter: 24 nTPM
medulla oblongata: 19 nTPM
pons: 15 nTPM
spinal cord: 14 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP8A as an antibody target. Whether an autoantibody or antibody against BMP8A could matter depends on whether native BMP8A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP8A is annotated as secreted, so native BMP8A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BMP8A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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